BACKGROUND Stabilization of rapid-cycling bipolar disorder is extremely difficult. METHODS A refractory bipolar I rapid-cycling patient on valproate was treated with long "nights" (extended sleep in darkness) and daytime light therapy. RESULTS Rapid cycling immediately stopped on initiation of a 10 hour dark/rest period. This was extended to 14 hours (plus a self-selected 1 hour midday nap)...

Background and objective: The prevalence of heart failure (HF) in the US has increased over several years. American Heart Association (AHA) documents that HF a 6 million cases among Americans aged 20 years older. is complex syndrome results from structural or functional impairment ventricular filling ejection blood, leading to symptoms including poor exercise tolerance, shortness breath, signs ...

Voung malt' N.n.il vulunlrtrs vtere dcnird unrmiil IHK lunidl slet-p and maintained on a 60-min Inalnn ill IM» min leslin|> schrdulr during 40 cunserulive hrs. Ten subjects bicycled, 20 subjects controlled lit. activity during bedrest. and 10 subjects napped. Kight measures of addition, auditor) vigilance, mood, and oral temperature were obtained. The Bedrest group showed significant impairment...

Insufficient stress response and elevated oxidative can contribute to skeletal muscle atrophy during mechanical unloading (e.g., spaceflight bedrest). Perturbations in heat shock proteins HSP70), antioxidant enzymes, sarcolemmal neuronal nitric oxidase synthase (nNOS) have been linked unloading-induced atrophy. We recently discovered that the NADPH oxidase-2 complex (Nox2) is unloading, downstr...

Hiperemesis Gravidarum merupakan Mual serta muntah berat selama masa kehamilan yang sering terjadi pada umur trimester pertama. Mabuk saat dapat sangat parah sehingga diklasifikasikan sebagai hiperemesis gravidarum. Akan tetapi, hal ini tidak terjadi. Gejala ibu merasakan mual hebat hingga merasa seperti ingin pingsan dan pusing jika berdiri. Hyperemesis gravidarum menyebabkan keadaan terus men...