Tumor-stimulated bone resorption fuels tumor growth and marks a dramatic decline in the health and prognosis of breast cancer patients. Identifying mechanisms that mediate cross-talk between tumor and bone remains a key challenge. We previously demonstrated that breast cancer cells expressing high levels of heparanase exhibit enhanced shedding of the syndecan-1 proteoglycan. Moreover, when thes...

Tilting pad journal bearings (TPJBs) are widely applied in the high-speed rotor system whose working speed is higher than its critical due to excellent hydrodynamic lubrication and stability. Pivot stiffness one of key design parameters TPJBs compared other has become particularly important for optimizing performance TPJB-rotor systems. In order improve vibration characteristics systems, transi...

The active control of hydrodynamic bearings is beginning to receive more attention in the pursuit lower power losses and reduced maintenance. This paper presents a method by which, from simple measurements, rich information can be deduced running bearing that used modify operating parameters unit. line-pivot, unidirectional, steadily loaded, directly lubricated tilting pad thrust bearing. achie...

The paper takes a type of flexible air bearing as the research object, and structure is analyzed in detail. Combined with traditional analysis method tilting pad fluid-solid coupling theory, new model for performance prediction was established. inner diameter 70mm calculated by changing input pressure or inlet capillary diameter. optimized analyzing calculation results, separate nozzle added. A...

A thermoelastohydrodynamic (TEHD) coupling model is developed to study the static performance of a heavy-duty tilting pad thrust bearing (TPTB) under effect axis misalignment. To ensure validity in calculating thermoelastic deformation, calculation accuracy mechanical and thermal deformations used TEHD verified by finite element method (FEM). The influence on flow state prediction determined us...

Hydrostatic bearings are superior in terms of their friction and load carrying characteristics when compared to contact based bearings, but non-usable applications with non-constant curvature counter surfaces. A possible solution this limitation is the introduction deformable hydrostatic components that cope these required deformations. To reduce deformation a single bearing pad, multiple pads ...

Weight loss in cancer cachexia is attributable to decreased food intake and/or enhanced energy expenditure. We investigated the roles of the uncoupling proteins (UCPs) UCPI, -2, and -3 in a murine model of cachexia, the MAC16 adenocarcinoma. Weight fell to 24% below that of non-tumor-bearing controls (P < 0.01) 18 days after MAC16 inoculation, with significant reductions in fat-pad mass (-67%; ...