Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduces ChAT enzyme activity and cellular protein levels, and is located within a highly-conserved N-terminal proline-rich motif at residues 14PKLPVPP20....

This paper investigates the development of accurate and efficient classifiers to identify misbehaving users (i.e., “flashers”) in a mobile video chat application. Our analysis is based on video session data collected from a mobile client that we built that connects to a popular random video chat service. We show that prior imagebased classifiers designed for identifying normal and misbehaving u...

Technology-driven interactions are becoming commonplace, particularly as online classes, telecommuting, and virtual meetings across distances time zones have all increased in popularity. Platforms such Google Meet, Skype, Webex, Zoom use synchronous audio-visual communication supported by text-based chat, emoticon responses, other supplementary functions. Given this uptick the of video conferen...

BACKGROUND Myenteric interneurones are involved in the reflexes that control the motility of the human colon. AIMS The distribution of choline acetyltransferase (ChAT) and nitric oxide synthase (NOS) immunoreactivity in myenteric interneurones was investigated in this study. METHODS DiI (1,1'- didodecyl 3,3,3',3'-indocarbocyanine perchlorate) was applied to the myenteric plexus of the human...

Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter acetylcholine (ACh), is thought to be present in kinetic excess in cholinergic neurons. The rate-limiting factor in ACh production is the provision of choline to ChAT. Cholinergic neurons are relatively unique in their expression of the choline transporter 1 (CHT1), which exhibits high-affinity for choline and ca...

The mouse gastro-intestinal and biliary tract mucosal epithelia harbor choline acetyltransferase (ChAT)-positive brush cells with taste cell-like traits. With the aid of two transgenic mouse lines that express green fluorescent protein (EGFP) under the control of the ChAT promoter (EGFP (ChAT) ) and by using in situ hybridization and immunohistochemistry we found that EGFP (ChAT) cells were clu...

This study investigates factors influencing live customer support chat services in Kuwait. Live Customer Support Chat represents a newly implemented type of customer service in E-commerce websites. Live Support Chat allows online agents through company’s websites to answer customer questions, complaints, and concerns on the spot through a live chat session, which bypasses the traditional e-mail...

One method for analyzing textual chat transcripts is a process called coding, whereby individual lines of chat, or blocks of chat, are assigned a topical label. This task is typically performed by humans, and takes a great deal of time. Automated analyses can reduce the amount of time it takes to code chat transcripts, and this paper presents the performance of the Naïve Bayes and Viterbi algor...