acanthamoeba keratitis is a vision- threatening infection and the most important risk factors are contact lenses characteristic symptoms include disproportionately severe ocular pain, epithelial ulcer, ring stromal infiltrate and resistance to antimicrobial treatment. the aim is to report the first cases of acanthamoeba keratitis in yazd in a retrospective study confirmed on histopathological a...

Monkeypox (MPXV) is a zoonosis with double-origin DNA (DNA), caused by monkeypox virus, an orthopox virus and close relative of variola (smallpox). It was first reported in central Africa 1970 has historically affected some the poorest most marginalized communities world. The clinical syndrome characterized fever, rash, lymphadenopathy. Complications can include pneumonitis, encephalitis, sight...

Objective: Bacterial keratitis occurs worldwide, and despite recent developments, it remains a potentially blinding condition. This study assesses the presence of herpes simplex virus (HSV-1 and -2) and varicella zoster virus (VZV) by quantitative real-time polymerase chain reaction (qPCR) in corneal scrapings from patients with bacterial keratitis. Methods: A total of 65 patients with clinic...

AIM To define the clinical and microbiological profile of bacterial keratitis at the Jules Gonin Eye Hospital and to test the in vitro bacterial resistance. METHODS Patients presenting with bacterial keratitis were prospectively followed; clinical features (age, risk factors, visual acuity) and response to therapy were analysed. Bacteriological profile was determined and the sensitivity/resis...

Staphylococcus aureus is a major pathogen in bacterial keratitis, a vision-threatening disease. Although the incidence of S. aureus keratitis varies worldwide, the increasing trend of resistance to certain antibiotics makes this condition an important, global, healthcare concern. We report the case of a 65-year-old woman with nosocomial left-eye corneal abscess and interstitial keratitis.The pa...

BACKGROUND Mycotic keratitis is an important cause of corneal blindness world over including India. Geographical location and climate are known to influence the profile of fungal diseases. While there are several reports on mycotic keratitis from southern India, comprehensive clinico-microbiological reports from eastern India are few. The reported prevalence of mycotic keratitis are 36.7%,36.3%...

The aim of this study was to prepare novel ocular mucoadhesive microspheres of Moxifloxacin HCl to increase its residence time on the ocular surface and to enhance its therapeutic efficacy in ocular bacterial keratitis. Microspheres were fabricated with different grades of Methocel and Sodium CMC as polymers. Microspheres were evaluated for their particle size, morphology, encapsulation efficie...

PURPOSE To report a case of infectious keratitis after small incision lenticule extraction (SMILE) treated with collagen cross-linking with photoactivated riboflavin (PACK-CXL). METHODS Case report and literature review. RESULTS A patient presented with culture-proven bacterial keratitis 5 days after SMILE was treated with fortified topical antibiotics and PACK-CXL. Irrigation of the cornea...

Background. The purpose was to analyze the cytokine balance of lacrimal fluid in patients with bacterial keratitis and diabetes mellitus (DM) at first visit identify immunological aspects disease. Materials methods. analysis pro- anti-inflammatory concentration performed 17 type 1 DM 15 nondiabetic visit. Data from 14 healthy individuals were used for comparison. In addition standard ones, opht...

Pseudomonas aeruginosa (P. aeruginosa) infection is one of the major causes keratitis. However, effective prophylactic and therapeutic vaccines against P. keratitis have yet to be developed. In this study, we explored use membrane vesicles (MVs) as a vaccine well immune sera derived from MV-immunized animals treatment for corneal infections in C57BL/6 mice. mice were intramuscularly immunized w...