Conjunctivitis, or inflammation of the conjunctiva, refers to a diverse group of ocular surface diseases of viral or bacterial origin that primarily affect the conjunctiva. In developed countries, the most common causative bacterial pathogens are Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pneumoniae. Most varieties of conjunctivitis are self-limiting; however, some cases c...

AIM To compare the efficacy and safety of levofloxacin 0.5% ophthalmic solution (Quixin) with placebo for treatment of bacterial conjunctivitis. METHODS In this prospective, randomised, placebo controlled, double masked, multicentre study, 249 patients with bacterial conjunctivitis received either 0.5% levofloxacin (n = 126) or placebo (n = 123) for 5 days, administered every 2 hours on days ...

PURPOSE To analyze the effect of azithromycin 1% ophthalmic solution in DuraSite (InSite Vision, Inc, Alameda, California, USA) on bacterial conjunctivitis. DESIGN Prospective, randomized, vehicle-controlled, parallel-group, double-masked multicenter clinical study. METHODS Eligible male or female participants with a clinical diagnosis of acute bacterial conjunctivitis were randomized to ei...

BACKGROUND Punctal plugs are used for the treatment of tear-deficient type dry eye. We recently examined a case of acute conjunctivitis associated with bacterial biofilm formation on a punctal plug. CASE A 63-year-old woman diagnosed as having tear-deficient type dry eye came to our hospital with a complaint of soreness in her right eye. Punctal plugs had been inserted into this eye 5 1/2 mon...

PURPOSE To assess clinical antimicrobial efficacy results obtained with besifloxacin ophthalmic suspension, 0.6%, administered three times a day (TID) for 5 days, integrated across three clinical trials of bacterial conjunctivitis and to investigate any microbiological eradication failures. METHODS Clinical microbiological eradication data from three randomized, double-masked, parallel group ...

PURPOSE The aim of this study was to evaluate the safety and efficacy of topical besifloxacin ophthalmic suspension 0.6% compared with gatifloxacin ophthalmic solution 0.3% in the treatment of bacterial conjunctivitis in neonates. METHODS This was a multicenter, randomized, double-masked, parallel group study. Subjects ≤31 days of age with severity grade ≥1 (scale 0-3) for both conjunctival d...

INDEX Page INTRODUCTION .. .. .. .. .. 143 PATHOLOGY .. .. .. .. .. .. 145 Pachymeningitis .. .. .. .. .. 145 Associated Lesions .. .. .. .. 147 CLINICAL PICTURE .. .. .. .. 148 REPORT OF A CASE TREATED BEFORE THE DISCOVERY OF PENICILLIN .. .. .. .. .. 149 BACTERIOLOGY .. .. .. .. .. 150 THEORY OF TREATMENT .. .. .. .. 151 EXPERIENCE SINCE THE INTRODUCTION OF PENICILLIN 152 Uncomplicated cases ...