نتایج جستجو برای: bacterial barrier

تعداد نتایج: 291925  

Journal: :Journal of Neuroimmunology 2011
Tatiana Barichello Joseandra S. Pereira Geovana D. Savi Jaqueline S. Generoso Andreza L. Cipriano Cintia Silvestre Fabricia Petronilho Felipe Dal-Pizzol Márcia Carvalho Vilela Antonio Lucio Teixeira

Bacterial meningitis is an inflammation of the meninges and subarachnoid space that occurs in response of bacteria. Young children are particularly vulnerable to bacterial meningitis, two thirds of meningitis deaths in low-income countries occur among children under the age of fifteen. The main bacterial pathogens causing meningitis beyond the neonatal period are Streptococcus pneumoniae, Haemo...

2013
Andreas Willerslev-Olsen Thorbjørn Krejsgaard Lise M. Lindahl Charlotte Menne Bonefeld Mariusz A. Wasik Sergei B. Koralov Carsten Geisler Mogens Kilian Lars Iversen Anders Woetmann Niels Odum

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in...

2015
Nikolai V Gorbunov Dennis P McDaniel Min Zhai Pei-Jyun Liao Bradley R Garrison Juliann G Kiang

The bone marrow stroma constitutes the marrow-blood barrier, which sustains immunochemical homoeostasis and protection of the haematopoietic tissue in sequelae of systemic bacterial infections. Under these conditions, the bone marrow stromal cells affected by circulating bacterial pathogens shall elicit the adaptive stress-response mechanisms to maintain integrity of the barrier. The objective ...

2013
Saskia van Hemert Jurre Verwer Burkhard Schütz

The intestinal barrier is important in preventing translocation of bacteria, toxins and antigens from the lumen of the gut into the body. Enhanced permeability, or gut leakiness, has been associated with different diseases. Probiotics can, strain-specifically, improve the epithelial barrier function. However, so far most researches have used cell lines or animal models due to the difficulty of ...

Journal: :Journal of pediatric surgery 2016
Anatoly Grishin Jordan Bowling Brandon Bell Jin Wang Henri R Ford

Necrotizing enterocolitis remains one of the most vexing problems in the neonatal intensive care unit. Risk factors for NEC include prematurity, formula feeding, and inappropriate microbial colonization of the GI tract. The pathogenesis of NEC is believed to involve weakening of the intestinal barrier by perinatal insults, translocation of luminal bacteria across the weakened barrier, an exuber...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2007
Henrik Köhler Takanori Sakaguchi Bryan P Hurley Benjamin A Kase Hans-Christian Reinecker Beth A McCormick

The establishment of tight junctions (TJ) between columnar epithelial cells defines the functional barrier, which enteroinvasive pathogens have to overcome. Salmonella enterica serovar Typhimurium (S. typhimurium) directly invades intestinal epithelial cells but it is not well understood how the pathogen is able to overcome the intestinal barrier and gains access to the circulation. Therefore, ...

Journal: :Molecular microbiology 2012
Anthony G Vecchiarelli Kiyoshi Mizuuchi Barbara E Funnell

The ParA family of ATPases is responsible for transporting bacterial chromosomes, plasmids and large protein machineries. ParAs pattern the nucleoid in vivo, but how patterning functions or is exploited in transport is of considerable debate. Here we discuss the process of self-organization into patterns on the bacterial nucleoid and explore how it relates to the molecular mechanism of ParA act...

Journal: :Ecology letters 2015
Roshan K Vijendravarma Sunitha Narasimha Sveta Chakrabarti Aurelie Babin Sylvain Kolly Bruno Lemaitre Tadeusz J Kawecki

The animal gut plays a central role in tackling two common ecological challenges, nutrient shortage and food-borne parasites, the former by efficient digestion and nutrient absorption, the latter by acting as an immune organ and a barrier. It remains unknown whether these functions can be independently optimised by evolution, or whether they interfere with each other. We report that Drosophila ...

Journal: :iranian journal of basic medical sciences 0
jakub krizak institute for heart research, slovak academy of sciences, bratislava, slovakia karel frimmel institute for heart research, slovak academy of sciences, bratislava, slovakia iveta bernatova institute of normal and pathological physiology, slovak academy of sciences, bratislava, slovakia jana navarova institute of experimental pharmacology and toxicology, slovak academy of sciences, bratislava, slovakia ruzena sotnikova institute of experimental pharmacology and toxicology, slovak academy of sciences, bratislava, slovakia ludmila okruhlicova institute for heart research, slovak academy of sciences, bratislava, slovakia

objective(s): occludin is essential for proper assembly of tight junctions (tjs) which regulate paracellular endothelial permeability. omega-3 polyunsaturated fatty acids (ω-3 pufa) protect endothelial barrier function against injury. materials and methods: we examined anti-inflammatory effect of ω-3 pufa intake (30 mg/kg/day for 10 days) on expression and location of occludin in the aorta of a...

Journal: :American journal of physiology. Cell physiology 2004
John McLaughlin Philip J Padfield Julian P H Burt Catherine A O'Neill

On interaction with the intestine, the mycotoxin ochratoxin A is know to cause rapid inflammation, diarrhea, and increased bacterial translocation. All these effects are consistent with a decrease in epithelial barrier function. However, this has not been shown directly. We determined that ochratoxin A is able to reduce the barrier properties of the model intestinal cell line Caco-2. Over 24 h,...

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