Beta-secretase is the first cleavage enzyme of amyloid-β protein precursor (AβPP) in the amyloidogenic pathway, leading to the formation of the plaque forming Amyloid-β (Aβ)1-42 peptide. BACE (beta-site AβPP cleaving enzyme) 1 inhibition is therefore considered to be a promising disease modifying therapy for Alzheimer's disease. An early assessment of the in vivo activity of BACE inhibitors was...

Exposure to air pollutants, including particulate matter, results in activation of the brain inflammatory response and Alzheimer disease (AD)-like pathology in dogs and humans. However, the length of time required for inhalation of ambient particulate matter to influence brain inflammation and AD pathology is less clear. Here, we studied the effect of 3 and 9 months of air particulate matter (<...

The transition from the terminal Ediacaran to early Cambrian (ca. 550−530 Ma) witnessed both decline of Ediacaran-type soft-bodied and skeletal biota rapid diversification Cambrian-type biota, which dominate Terreneuvian 538.8−521 fossil record. This interval hosts globally widespread positive negative δ13Ccarb excursions, including a excursion near Ediacaran-Cambrian boundary termed 1n/BACE. E...

Simulating protein flexibility is a major issue in the docking-based drug-design process for which a single methodological solution does not exist. In our search of new anti-Alzheimer ligands, we were faced with the challenge of including receptor plasticity in a virtual screening campaign aimed at finding new β-secretase inhibitors. To this aim, we incorporated protein flexibility in our simul...

1 Proton-conducting ceramics 2 BaCe 0.2 Zr 0.7 Y 0.1 O 3-δ ceramics, which selectively separate H from any hydrogen-containing gas could play a role in the future of growing hydrogen market. In recent years, membrane technologies related to extraction became attractive solutions produce pressurized high-purity hydrogen. Yttrium-doped barium zirconate/cerate materials (BaCe x 1-x-y y ) are among...

The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD). Here we show that seladin-1-deficient mouse brains had reduced levels of cholesterol and disorganized...