نتایج جستجو برای: b and t lymphocyte attenuator

تعداد نتایج: 17065848  

Journal: :Cancers 2021

The herpes virus entry mediator (HVEM) delivers a negative signal to T cells mainly through the B and lymphocyte attenuator (BTLA) molecule. Thus, HVEM/BTLA may represent novel immune checkpoint during an anti-tumor response. However, formal demonstration that HVEM can target for cancer immunotherapy is still lacking. Here, we first showed BTLA mRNA expression levels were associated with worse ...

Journal: :acta medica iranica 0
massoud.a lotfi.j derakhshan.i ala.f

thirty seven randomly selected patients suffering from multiple s c l e r os i s (ms) (17 males and 20 females)and 30 healthy control subjects were studied for the lymphocyte subpopulations and ce l l -medi a t e d immunity.we obs e r ved a decrease of the total t-cells and an increase of a ctive t-lymphocytes and b ce l l s , in ms p at i ent s as compared t o normal controls. the inability of...

2016
Zi Ye Bolin Deng Chaokui Wang Dike Zhang Aize Kijlstra Peizeng Yang

Behcet's disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response. In this study, we investigated whether BTLA activation could be exploited to inhibit the development of abnormal immune responses in BD patients. BT...

Journal: :Journal of leukocyte biology 2004
Gérald J Prud'homme

The etiology of most human autoimmune diseases remains largely unknown. However, investigators have identified several negative regulatory mechanisms acting at the level of innate and/or adaptive immunity. Mutations resulting in a deficiency of some key regulatory molecules are associated with systemic or organ-specific inflammatory disorders, which often have a prominent autoimmune component. ...

Journal: :Journal of immunology 2012
Maria-Luisa del Rio Nick D Jones Leo Buhler Paula Norris Yasushi Shintani Carl F Ware Jose-Ignacio Rodriguez-Barbosa

The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT; TNFSF14), and the inhibitory Ig family member B and T lymphocyte attenuator (BTLA). To dissect t...

2015
Seiji Oguro Yoshinori Ino Kazuaki Shimada Yutaka Hatanaka Yoshihiro Matsuno Minoru Esaki Satoshi Nara Yoji Kishi Tomoo Kosuge Nobuyoshi Hiraoka

The host immune system plays a significant role in tumor control, although most cancers escape immune surveillance through a variety of mechanisms. The aim of the present study was to evaluate the clinicopathological significance of a novel co-inhibitory receptor, B and T lymphocyte attenuator (BTLA), the anergy cell marker Casitas-B-lineage lymphoma protein-b (Cbl-b), and clinical implications...

Journal: :The Journal of infectious diseases 2011
Zheng Zhang Xiangsheng Xu Jiyun Lu Shuye Zhang Lanlan Gu Junliang Fu Lei Jin Haiying Li Min Zhao Jiyuan Zhang Hao Wu Lishan Su Yang-Xin Fu Fu-Sheng Wang

BACKGROUND Nonspecific T-cell hyperactivation is the main driving force for human immunodeficiency virus (HIV)-1 disease progression, but the reasons why the excess immune response is not properly shut off are poorly defined. METHODS Eighty-five HIV-1-infected individuals were enrolled to characterize B and T lymphocyte attenuator (BTLA) expression and function. Infection and blockade assays ...

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