In dynamic covalent chemistry, reactions follow a thermodynamically controlled pathway through equilibria. Reversible covalent-bond formation and breaking in process enables the interconversion of products formed under kinetic control to more stable isomers. Notably, enantioselective catalysis transformations has not been reported applied complex molecule synthesis. We describe discovery metal-...

Design and synthesis of pseudo-natural products (PNPs) through recombination natural product (NP) fragments in unprecedented arrangements enables the discovery novel biologically relevant chemical matter. With a view to wider coverage NP-inspired biological space, we describe combination this principle with macrocycle formation. PNP-macrocycles were synthesized efficiently stereoselective one-p...

A wide range of new dipoles and catalysts have been used in 1,3-dipolar cycloadditions of N-metalated azomethine ylides onto C60 yielding a full stereodivergent synthesis of pyrrolidino[60]fullerenes with complete diastereoselectivities and very high enantioselectivities. The use of less-explored chiral α-iminoamides as starting 1,3-dipoles leads to an interesting double asymmetric induction re...

This present mini-review covers recently published results on Cu(I) and Cu(II) complexes immobilized on polystyrene carriers, which are used as heterogeneous, eco-friendly reusable catalysts applied for carbon-carbon and carbon-nitrogen forming reactions. Recent advances and trends in this area are demonstrated in the examples of oxidative homocoupling of terminal alkynes, the synthesis of prop...

(1) Chromium(0)-Catalyzed Tandem Cyclization of α,β-Unsaturated Thioimidates Containing an Enyne Moiety Karibe, Y.; Kusama, H.; Iwasawa, N.* Angew. Chem. Int. Ed. in press. (2) Efficient Control for the Cationic Platinum(II)-Catalyzed Concise Synthesis of Two Types of Fused Carbocycles with Angular Oxygen Functionality Kusama, H.; Watanabe, E.; Ishida, K.; Iwasawa, N.* Chem.–Asian J. 2011, 6, 2...