osting by E C BY-NCAbstract Azadirachta indica is widely used in traditional medicine to treat diabetes and hypertension. In the present study A. indica-yogurt was prepared and refrigerated up to 28 days. pH of A. indica-yogurt was lower whereas total titratable acid (TTA) was higher than plain-yogurt during storage. The total phenolic content (TPC) and antioxidant capacity increased during sto...

Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1-3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 an...

Different strength of alcohol 40.50,60,70,80,90 per cent (v/v) and absolute were utilized for the preparation of tincture of azadirachta Indica A. Juss leaves by maceration for 7, 14,21 days. 60 per cent tincture produced after 21 says of maceration showed a maximum solid content of 1.425 per cent (v/v) and sowed pH 3.15. This tincture was characterized by studying is various physico-chmicla pr...

BACKGROUND Different strains of influenza virus are affecting a large number of people worldwide. Many synthetic antiviral medicines are available for influenza virus in the market. But still there is a need for the development of universal drugs against these strains of influenza virus. METHODS For this purpose conserved residues within the influenza virus nucleoprotein have been retrieved. ...

Pseudomonas aeruginosa is well known for its ability to form biofilm on indwelling medical devices. These biofilms are difficult to remove because of their high tolerance to conventional antibiotics. Therefore, there is a need to look for alternative agents such as medicinal plants, which can eradicate or inhibit biofilm effectively. This study evaluated the role of neem in inhibiting biofilm f...

The efficacy of different concentrations of aqueous neem leaf extract (3.12 to 50 mg/mL) on growth and citrinin production in three isolates of Penicillium citrinum was investigated under laboratory conditions. Mycotoxin production by the isolates was suppressed, depending on the concentration of the plant extract added to culture media at the time of spore inoculation. Citrinin production in f...

Neem (Azadirachta indica A. Juss.), an evergreen tree of the Meliaceae family, is known for its medicinal, cosmetic, pesticidal and insecticidal properties. We had previously sequenced and published the draft genome of a neem plant, using mainly short read sequencing data. In this report, we present an improved genome assembly generated using additional short reads from Illumina and long reads ...

Nimbidin the major bitter principle from oil of seeds of Azadirachta indica A. Juss was investigated for various pharmacological actions in a number animal models. On central nervous system it exhibited moderate sedative effect it did not show any significant cardiovascular effects in experimental animals. Autonomic pharmacological studies (in-vitro) revealed pronounced anticholinergic antihist...

Azadirachta indica A. Juss (Meliaceae) is indige­ nous to the Indo-Pakistan subcontinent and its various parts are reputed as therapeutic agents [2, 3]. Some of the constituents of neem have recently been shown to possess significant pesticidal activity [4]. More recent studies undertaken on the fresh, un­ dried, uncrushed, ripe and unripe, fruits and the un­ dried leaves of the plant by Siddiq...

The effect of neem, Azadirachta indica A. Juss, on ultrastructural alteration of larvae and puparia of the blow fly, Chrysomya megacephala (Fabricius) (Diptera: Calliphoridae) and house fly, Musca domestica (Linnaeus) (Diptera: Muscidae), was investigated in the laboratory by using neem extract containing 0.24% azadirachtin A. Larvae of both species exposed to single dipping with the neem produ...