Objectives: To compare the effectiveness of two treatment methods of ‘combination pharmacological treatment and treadmill training’ and ‘pharmacological treatment’ on management of multiple sclerosis (MS) female patients. Methods: In this quasi experimental and interventional study a sample of 20 MS patients (mean age: 36.75 years) with Expanded Disability Status Scal...

One important step in modern treatment of multiple sclerosis is recent FDA approval for oral imunomodulatory therapy in the last months of 2010. Multiple Sclerosis (MS), an autoimmune disease of the central nervous system, that is chronic and progressive, affects more than 2.1 million worldwide. The most common form of the disease is relapsing-remitting, characterized by exacerbations intersper...

OBJECTIVE To describe the current understanding of the diagnosis and treatment of multiple sclerosis (MS) and to explore the use of magnetic resonance imaging (MRI) assessment as a prognostic tool and an indicator in the diagnosis of MS. SUMMARY MS is a chronic, progressive, demyelinating disease of the central nervous system that is associated with a significant economic burden. At this time...

OBJECTIVE To introduce a model treatment algorithm for use in the managed care setting as a strategy to provide ongoing disease management and long-term care for patients with multiple sclerosis (MS), with the goal of delaying disease progression and the associated disability and cognitive dysfunction. SUMMARY MS is a chronic inflammatory disorder of the central nervous system that is associa...

objectives: to compare the effectiveness of two treatment methods of ‘combination pharmacological treatment and treadmill training’ and ‘pharmacological treatment’ on management of multiple sclerosis (ms) female patients. methods: in this quasi experimental and interventional study a sample of 20 ms patients (mean age: 36.75 years) with expanded disability status scale scores (edss) 1.0 to 4.0 ...

The genetics of natalizumab hypersensitivity One learns to itch where one can scratch Many of the immune therapies that are currently approved or in development for patients with multiple sclerosis (MS) are potentially immunogenic recombinant proteins. 1 Some of these proteins have amino acid substitutions, while others may differ from their endogenous counterparts by posttransla-tional modific...

A common feature of organ-specific autoimmune disorders is a broad disease spectrum, which ranges from self-limited acute illnesses to relapsing or more chronic and fatal forms. The variation is less in disorders in which a threshold effect must be exceeded to result in symptoms, as in juvenile diabetes. However, a wide spectrum occurs in most autoimmune disorders, including uveitis, non-infect...

Interferons (IFNs), first recognised because of their antiviral properties, are a key defence mechanism involved in the control of virus infections. They are small proteins separated by nucleated cells in response to viral infection or other appropriate stimuli, and are thought to act principally on other cells in their immediate vicinity. They are divided into two types: type 1 comprises IFN-á...