نتایج جستجو برای: autoantibody

تعداد نتایج: 6541  

Journal: :Pediatric Research 2001

Journal: :Journal of Clinical Investigation 1962

Journal: :Journal of Neurology, Neurosurgery & Psychiatry 2017

2011
Andrea K. Steck Kelly Johnson Katherine J. Barriga Dongmei Miao Liping Yu John C. Hutton George S. Eisenbarth Marian J. Rewers

OBJECTIVE We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantibodies. RESEARCH DESIGN AND METHODS The Diabetes Autoimmunity Study in the Young (DAISY) followed 2,542 children with autoantibodies measured to GAD, IA-2, and insulin. RESULTS Persistent islet autoantibodies developed in 169 subjects, and 55 of those progressed...

2012
Emel Guler Ece Kaptanoglu Ozlem Sahin Ferhan Candan Emrullah Hayta Hasan Elden

Objective: It has been suggested that Mediterranean fever (MEFV) gene mutations are also seen in certain autoimmune diseases and are related to severity of the disease activity. As most of the clinical symptoms of these inflammatory diseases are related to autoantibody positivity, we assessed autoantibody prevalence in patients with Familial Mediterranean fever (FMF) and investigated the relati...

Journal: :Blood 1989
P Berchtold G L Dale P Tani R McMillan

Intravenous immunoglobulin (IVIgG) causes an acute rise in the platelet count in the majority of patients with chronic immune thrombocytopenic purpura (ITP) but the mechanism(s) of action is still unknown. We evaluated the ability of three different IVIgG preparations to inhibit the in vitro binding of autoantibody to platelet glycoprotein (GP) IIb/IIIa. ITP plasma, known to contain anti-GPIIb/...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014
Jérôme Lacombe Alain Mangé Anne-Claire Bougnoux Ioannis Prassas Jérôme Solassol

BACKGROUND The sensitivity of mammography for the detection of small lesions, including node-negative early-stage (T1N0) primary breast cancer (PBC) and ductal carcinoma in situ (DCIS), is significantly decreased in young patients. From a clinical standpoint, an inconclusive mammogram reflects the inability of clinicians to confidently decide whether patients should be referred for biopsy or fo...

2016
Alberto Pugliese David Boulware Liping Yu Sunanda Babu Andrea K. Steck Dorothy Becker Henry Rodriguez Linda DiMeglio Carmella Evans-Molina Leonard C. Harrison Desmond Schatz Jerry P. Palmer Carla Greenbaum George S. Eisenbarth Jay M. Sosenko

The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype is linked to protection from the development of type 1 diabetes (T1D). However, it is not known at which stages in the natural history of T1D development this haplotype affords protection. We examined a cohort of 3,358 autoantibody-positive relatives of T1D patients in the Pathway to Prevention (PTP) Study of the Type 1 Diabetes TrialNet. The P...

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