Water-soluble Ag-Au bimetallic nanostructures were prepared via co-reduction and seed-mediated growth routes employing poly-(4-styrenesulfonic acid-co-maleic acid) (PSSMA) as both a reductant and a stabilizer. Ag-Au alloy nanoparticles were obtained by the co-reduction of AgNO3 and HAuCl4, while Ag-Au core-shell nanostructures were prepared through seed-mediated growth using PSSMA-Au nanopartic...

The nanosphere lithography (NSL) method can be developed to deposit the Au-Ag triangle hexagonal nanoparticle arrays for the generation of localized surface plasmon resonance. Previously, we have found that the parameters used to form the NSL masks and the physical methods required to deposit the Au-Ag thin films had large effects on the geometry properties of the nanoparticle arrays. Consideri...

High thiophillicicity of the Au-nanoparticle (Au NP) surface leads to covalent attachment of D-penicillamine molecules to Au NPs to form biocompatible D-penicillamine conjugated Au NPs. The latter are highly water-dispersible, exhibit no cytotoxicity, and can readily penetrate the cell membrane to target intracellular free copper ions for selective copper detoxification in the presence of the o...

An analytical platform coupling asymmetric flow field-flow fractionation (AF(4)) with multiangle light scattering (MALS), dynamic light scattering (DLS), and inductively coupled plasma mass spectrometry (ICPMS) was established and used for separation and quantitative determination of size and mass concentration of nanoparticles (NPs) in aqueous suspension. Mixtures of three polystyrene (PS) NPs...

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstrati...

A nanoparticle drug carrier system has been developed to alter the cellular uptake and chemotherapeutic performance of an available chemotherapeutic drug. The system comprises of a multifunctional gold nanoparticle based drug delivery system (Au-PEG-PAMAM-DOX) as a novel platform for intracellular delivery of doxorubicin (DOX). Spherical gold nanoparticles were synthesized by a gold chloride re...

UV-SERS measurements offer a great potential for environmental or food (detection of food contaminats) analytics. Here, the UV-SERS enhancement potential of various kinds of metal colloids, such as Pd, Pt, Au, Ag, Au-Ag core-shell, and Ag-Au core-shell with different shapes and sizes, were studied using melamine as a test molecule. The influence of different activation (KF, KCl, KBr, K(2)SO(4))...

Gold nanoparticles immobilized on gold surfaces (AuNPs/Au) function as an excellent SERS substrate for the detection of bacteria biomarkers. The possibility of the reactivity of bacteria biomarkers on such a nanoparticle-based substrate poses complications for the spectroscopic identification and quantification. This report describes new findings of an investigation of the SERS characteristics ...

The complex surface structure of gold-thiolate nanoparticles is known to affect the calculated density functional theory (DFT) excitation spectra. However, as the nanoparticle size increases, it becomes impractical to calculate the excitation spectrum using DFT. In this study, a new method is developed to determine the energy levels of the thiolate-protected gold nanoparticles [Au(25)(SR)(18)](...