OBJECTIVE Dual-phase (99m)Tc-sestamibi (methoxyisobutylisonitrile [MIBI]) imaging is the technique of choice for hyperparathyroidism (HPT), especially for localizing parathyroid adenomas. Prior studies have shown its utility for detecting hyperplasia is equivocal, but we believe this is not true. We attempted to quantitate the region-of-interest counts per pixel between immediate images and del...

BACKGROUND Distinction of parathyroid cancer from atypical parathyroid adenoma (APA) at operation is difficult. The aim of this study was to determine whether parathyroid cancer and APA have different operative findings and long-term outcomes. METHODS A retrospective review was undertaken of patients with suspicious or malignant parathyroid tumours treated between 1974 and 2005. Parathyroid c...

BACKGROUND Radioguided surgery using 99m-Technetium-methoxyisobutylisonitrile (99mTc-MIBI) has been recommended for the surgical treatment of mediastinal parathyroid adenomas. However, high myocardial 99mTc-MIBI uptake may limit the feasibility of radioguided surgery in aortopulmonary window parathyroid adenoma. CASE PRESENTATION Two female patients aged 72 (#1) and 79 years (#2) with primary...

A 33 year old female patient presented with history of body and joint pain easy fatiguability unable to perform her routine daily activities since 2 months. She also gave recurrent urinary tract infections, abdomen, loss appetite weight. Examination neck showed no palpable mass. Laboratory data revealed elevated serum calcium levels parathyroid hormone levels. Contrast enhanced computed tomogra...

The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aort...

Background: Radioguided surgery using 99m-Technetium-methoxyisobutylisonitrile (Tc-MIBI) has been recommended for the surgical treatment of mediastinal parathyroid adenomas. However, high myocardial Tc-MIBI uptake may limit the feasibility of radioguided surgery in aortopulmonary window parathyroid adenoma. Case presentation: Two female patients aged 72 (#1) and 79 years (#2) with primary hyper...

of an ectopic, overly-descended superior parathyroid adenoma in both primary and reoperative parathyroid surgery. Methods: A prospective analysis of consecutive patients undergoing parathyroid surgery in a tertiary endocrine surgery practice from March 2004 to April 2013 was undertaken. All patients undergoing curative primary or reoperative surgery for single-gland parathyroid adenomas were id...

Primary hyperparathyroidism is defined by elevated parathyroid hormone and calcium levels, most usually caused a adenoma. Parathyroid adenomas are commonly detected in the neck or an ectopic site, seldom mediastinum. The adenoma can occur locations such as mediastinum, thymus, retro oesophagal area 6-16% of cases. We presented example 73-year-old woman who was found to have hypercalcemia during...

BACKGROUND Intraneural parathyroid adenomas are rare, with only 9 cases of intravagal adenomas reported. All but one of the reported cases was found after multiple neck explorations. To the best of our knowledge, we report the first case of nonsupernumerary ectopic intravagal parathyroid identified at primary exploration. METHODS AND RESULTS A 17-year-old girl with primary hyperparathyroidism...

We report a case of retroesophageal parathyroid adenoma coexisting with an aberrant right subclavian artery (ARSA). A 63-year-old female presented with elevated serum calcium and intact parathyroid hormone levels. 99mTc-methoxyisobutylisonitrile scintigram and enhanced chest computed tomography (CT) revealed a mediastinal tumor measuring 25×15×7 mm located posterior to the esophagus. Three-dime...