BACKGROUND AND PURPOSE VB artery stenosis is associated with a high risk of recurrent ischemic events, and knowledge about the hemodynamic relevance of VB stenosis is important for clinical decision making. In this study, multiple inflow pulsed ASL MR imaging was assessed for its ability to measure CBF and ATT in patients with VB disease. MATERIALS AND METHODS ASL was performed on a 3T MR ima...

Type 2 diabetes is characterized by raised blood glucose levels caused by an insufficient insulin control of glucose homeostasis. This lack of control is expressed both through insufficient release of insulin by the pancreatic beta-cells, and through insulin resistance in the insulin-responding tissues. We find insulin resistance of the adipose tissue particularly interesting since it appears t...

Modern electronics has revolutionized the way information is processed and stored in our society. In health care and in biology it is of great interest to utilize technology to regulate physiology and to control the signaling pathways. Therefore, the coupling of electronic signals to biological functions is of great importance to many fields within the life sciences. In addition to the conventi...

In several neurodegenerative disorders, including Alzheimer disease (AD) and Parkinson disease (PD), protein aggregation is accompanied by mitochondrial dysfunction. An increasing number of proteins found in mitochondria have multiple localizations. The Amyloid β-peptide precursor protein (APP), a key protein in AD, has a chimeric targeting signal (endoplasmic reticulum (ER) + mitochondria). AP...

Långvarig smärta är en stor patientgrupp. Omkring 30-40 procent av befolkningen lider av långvarig smärta av sådan grad att det stör vardagslivet. Tio procent har så smärta att det invalidiserar i någon grad. Långvarig smärta är att betrakta som ett folkhälsoproblem men är samtidigt ett eftersatt område trots en beräknad total samhällskostnad på årliga 85 miljarder kronor i Sverige. Det är inge...

A number of animal species have undergone domestication, the process of becoming adapted to living in captivity and in proximity to humans. Common for these species is that they have all developed certain traits, including changes to coat color, body size and level of fearfulness. This has been termed the domestic phenotype. Among these traits is also an attenuation of the response to stress, b...

Experimental innovations starting in the 1990’s leading to the advent of highthroughput experiments in cellular biology have made it possible to measure thousands of genes simultaneously at a modest cost. This enables the discovery of new unexpected relationships between genes in addition to the possibility of falsify existing. To benefit as much as possible from these experiments the new inter...

This project explored how the language technology method Random Indexing can be used for clustering of texts from Swedish newspapers. The resulting Random Indexing based representation yields similar results as an ordinary representation when the number of clusters matches the real categories. With an increased number of clusters the Random Index based representation yields better results than ...

Bacteriophage-encoded serine recombinases have great potential in genetic engineering but their catalytic mechanisms have not been adequately studied. Integration of ϕBT1 and ϕC31 via their attachment (att) sites is catalyzed by integrases of the large serine recombinase subtype. Both ϕBT1 and ϕC31 integrases were found to cleave single-substrate att sites without synaptic complex formation, an...

Satelliter är sofistikerade och därför komplicerade konstruktioner som kräver tvärvetenskapligt lagarbete mellan olika experter från olika akademiska discipliner. Integrationen av specifika nyttolastkomponenter, liksom vetenskapliga experiment, med inbyggd programvara för satelliter är mycket utmanande. Domänexperten, som ägare av nyttolastkomponenten, besitter detaljerade insikter om hans elle...