We have defined the pharmacokinetics of atracurium besylate 0.25 mg kg-1 in 41 patients anaesthetized with 0.9% isoflurane end-tidal, 0.5% halothane end-tidal or midazolam 3-10 mg as a supplement to 66% nitrous oxide in oxygen. The pharmacokinetic profile was affected by age, sex and anaesthetic technique. Advancing age was associated with a reduced clearance and a longer elimination half-time;...

purpose: although there are ample evidences for the effects (mostly decrease) of intraocular pressure (iop) after the administration of atracurium and cisatracurium during general anesthesia in ophthalmic operations, no study has yet been done to compare their effects on both iop and pupillary diameter (pd) simultaneously. the aim of this study was to determine whether there is any difference b...