We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

In asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. If this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. In order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalat...

INTRODUCTION  Changes in the respiratory system of asthmatics are also due to the mechanical disadvantage caused by the increased airway resistance. OBJECTIVE  The study aims to evaluate the respiratory muscle strength and nutritional status of asthmatic children. METHOD  This is a prospective descriptive and transversal study with 50 children aged 7 to 12 years, who were placed into 2 grou...

Objective: Previous studies indicated anti-inflammatory effects for Portulaca oleracea in various inflammatory disorders. In this study, the effects of P. oleracea on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2(PLA2) and IgE in sensitized rats were examined. Materials and Methods: Male rats were randomly divided into six groups namely, control (group C), s...

chronic  obstructive  pulmonary  disease (copd)  and  asthma  are  major  public  health problems, which seems to have close association with psychiatric disorders. the present study was conducted to compare the psychological status between asthmatic and copd patients and clarify the relationship with severity of pulmonary obstruction. this cross-sectional study was planned to compare the psych...

obesity as a common health risk is increasing all over the world. the aim of this study was evaluation of standing and sitting positions on spirometric values in obese asthmatic patients, in comparison with normal obese subjects. the study included 49 obese asthmatic patients with mean age of 42.63 years and body mass index of 36.06 kg/m 2 , and 51 control obese normal subjects with mean age of...

background: asthma is a chronic inflammatory disease with multifactorial and complicated mechanisms. elevated level of exhaled nitric oxide (no) in asthma and other inflammatory lung diseases has led to many studies examining no as a potential marker of airway inflammation. objective: this study was designed to determine the level of no in bronchoalveolar lavage (bal) fluid during early and lat...