Berkowitz (this issue) makes a cogent case for his cognitive neo-associationist (CNA) model that some aggressive behaviors occur automatically, emotionally, and through conditioned association with other stimuli. He also proposes that they can occur without "processing," that is, without meaning. He contrasts his position with that of social information processing (SIP) models, which he casts a...

Nurse practitioners (NPs) are “registered nurses with additional educational preparation and experience who possess and demonstrate the competencies to autonomously diagnose, order and interpret diagnostic tests, prescribe pharmaceuticals and perform specific procedures within their legislated scope of practice” (Canadian Nurses Association [CNA], 2006, p. 19). The NP role is derived “from blen...

Several radioactive particles from the Palomares area have been analyzed with the nuclear microprobe of the National Accelerator Centre (CNA) in Seville exploring the advantages of combining -PIXE using a 5.5MeV 4He beam with conventional -PIXE analysis using 3MeV protons. The measurements performed with the -particles are more sensitive to the sample surface, while the results collected with p...

BACKGROUND AND OBJECTIVE For the conduct of controlled clinical trials, epidemiologic surveys or even of medical practice of varieties of peripheral neuropathy, the usefulness, error rate and cost-effectiveness of scannable case-report forms has not been studied. MATERIALS AND METHODS The overall performance, the frequency of the problems identified and corrected, and the time saved from use ...

PURPOSE To pilot test a multicomponent intervention to increase certified nursing assistants' (CNAs) awareness of person-centered care. To establish the feasibility of implementing an intervention involving videotaped biographies of residents and videotapes of resident/CNA caregiving interactions. DESIGN AND METHODS A training program was provided at two nursing homes (NHs) using a wait-list ...

The rise of DNA evidence to the forefront of forensic science has led to high sample numbers being submitted for profiling by investigators to casework laboratories: bottleneck effects are often seen resulting in slow turnaround times and sample backlog. The ParaDNA(®) Screening and Intelligence Tests have been designed to guide investigators on the viability of potential sources of DNA allowin...

CNAnorm is a package for the analysis of Copy Number Alteration (CNA) of tumour samples using low coverage (around 0.01 0.5X) high throughput sequencing[1]. In particular, CNAnorm aims to perform a meaningful normalisation of the sample by estimation of the underlying tumour’s ploidy. CNAnorm allows both a fully automated as well as an interactive approach to the normalisation step. It provides...

Cancer is a genomic disease associated with a plethora of gene mutations resulting in a loss of control over vital cellular functions. Among these mutated genes, driver genes are defined as being causally linked to oncogenesis, while passenger genes are thought to be irrelevant for cancer development. With increasing numbers of large-scale genomic datasets available, integrating these genomic d...

The genome-wide discoveries such as detection of copy number alterations (CNA) from high-throughput whole-genome sequencing data enabled new developments in personalized medicine. The CNAs have been reported to be associated with various diseases and cancers including acute myeloid leukemia. However, there are multiple challenges to the use of current CNA detection tools that lead to high false...

SUMMARY We present a tool for control-free copy number alteration (CNA) detection using deep-sequencing data, particularly useful for cancer studies. The tool deals with two frequent problems in the analysis of cancer deep-sequencing data: absence of control sample and possible polyploidy of cancer cells. FREEC (control-FREE Copy number caller) automatically normalizes and segments copy number ...