BACKGROUND AND PURPOSE Aspirin is used commonly to prevent ischemic strokes and other vascular events. Although aspirin is considered safe and effective, it has limited efficacy with a relative risk reduction of 20% to 25% for ischemic stroke. We sought to determine if aspirin as currently used is having its desired antiplatelet effects. METHODS We ascertained patients with cerebrovascular di...

BACKGROUND Accumulated data suggest that low-dose aspirin after myocardial infarction (MI) may offer similar efficacy to higher dose aspirin with reduced risk of bleeding. Few data are available on contemporary aspirin dosing patterns after MI in the United States METHODS AND RESULTS Aspirin dosing from 221 199 patients with MI (40.2% ST-segment-elevation MI) from 525 US hospitals enrolled in...

introduction: pain research using animal models is related to ethical concerns, so invertebrates and insects have been recommended by researchers. in the present study, the nociceptive and antinociceptive effects of capsaicin, aspirin, morphine and chili extract were examined using fruit fly (drosophila melanogaster) as an alternative for rodent pain model. methods: stage 3 of larvae and adult ...

Aspirin and other nonsteroidal anti-inflammatory medicines (NSAIDs) have been shown in a large body of research to be protective against the growth adenomas colon cancer. possible benefit NSAIDs like aspirin preventing CRC. Other factors also found, mostly through observational research, but potency some these correlations is not clear. Dietary regimens certain kind may lower risk

BACKGROUND A special regulatory role for prostaglandin E2 has been postulated in aspirin-induced asthma. A study was undertaken to investigate the effects of aspirin on the systemic production of prostaglandin E2 and cysteinyl leucotrienes in patients with asthma. METHODS The urinary concentrations were determined of two main prostaglandin E2 metabolites (13,14-dihydro-15keto-PGE2 using a com...

Objective—Aspirin blocks thromboxane production that contributes to its well-appreciated antiplatelet action. Aspirin also initiates the biosynthesis of novel antiinflammatory mediators from arachidonic acid, namely aspirin-triggered 15-epi-lipoxin A4. We recently conducted a double-blinded clinical trial with healthy subjects in whom low-dose aspirin (81 mg daily) significantly increased aspir...

Introduction and Aim: Adverse pregnancy outcomes (APO’s-preterm birth, foetal growth restriction hypertensive disorders of (HDP)) are the primary drivers perinatal mortality. C-Reactive Protein, Anti-Mullerian Hormone (AMH) Alpha-FetoProtein (AFP) have shown promise in predicting these APO’s. Aim this present work is to validate predictive ability biomarkers identify women at risk for preterm b...

Background: Aspirin use is extensive, but its short half-life limits bioavailability. Results: Butyrylcholinesterase and PAFAH1b2 hydrolyze aspirin in plasma. Aspirin hydrolysis in plasma varies up to 12-fold from non-genetic modulation of butyrylcholinesterase activity. Conclusion: Two enzymes hydrolyze aspirin in plasma and their contribution varies among individuals. Significance: Aspirin hy...

IMPORTANCE Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population. OBJECTIVE To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors. DESIGN, SETTING, AND PARTICIPANTS The Japanese Primary Prevention Project (JPPP...

Background and Purpose Despite its low efficacy, aspirin is the most widely used drug for secondary stroke prevention. The reasons why stroke recurs while patients are on aspirin are unknown. We have analyzed a series of patients who had recurrent strokes while on aspirin. Methods Out of 2231 consecutive patients who were admitted to the Tel Aviv Medical Center from May 1988 through December 19...