Nerve cells form elaborate, highly branched dendritic trees that are optimized for the receipt of synaptic signals. Recent work published in this issue of Genes & Development by Rosario and colleagues (pp. 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branching of dendrites by neurons in the top layers of the mouse cortex. The results raise interestin...

Commercial pressures on time-to-market often require the development of software in situations where deadlines are very tight and non-negotiable. This type of development can be termed ‘time-constrained software development.’ The need to compress development timescales influences both the software process and the way it is managed. Conventional approaches to modelling tend to treat the developm...

England financed its war of the Austrian succession (1743-48) mainly by issuing 3% bonds and 4% callable bonds which were indeed redeemed by Pelham in 1749 through an interest reduction. Implicit policy rules and constraints made the 4% bond a derivative asset of a 3% perpetual. The price data fit with a model of pricing of this derivative. The estimated model shows that the redemption terms we...

The glucose-6-phosphatase system catalyses the terminal step of hepatic glucose production from both gluconeogenesis and glycogenolysis and is thus a key regulatory factor of blood glucose homoeostasis. To identify the glucose 6-phosphate transporter T1, we have performed photoaffinity labelling of human and rat liver microsomes by using the specific photoreactive glucose-6-phosphate translocas...

Accreting stellar mass black holes (BHs) routinely exhibit Type-C quasi-periodic oscillations (QPOs). These are often interpreted as Lense-Thirring precession of the inner accretion flow, a relativistic effect whereby the spin of the BH distorts the surrounding space-time, inducing nodal precession. The best evidence for the precession model is the recent discovery, using a long joint XMM-Newto...

En este artículo se analizan los datos de un padrón Pozos, Guanajuato, 1743, para conocer aspectos fundamentales su sociedad, como la estructura por grupos edad; cruzó información con bautizos y entierros identificar mortalidad, natalidad fecundidad. Se midió confiabilidad edad declarada índices Whipple Myers. identificaron tipos hogares acuerdo tipología Laslett, además discute calidad reporta...

An analysis of attenuation and absorption lengths of the electron number using data of the KASCADE air shower experiment is presented. The following methods are used to determine these quantities: The method of constant intensity, the attenuation of the electron number at the knee with increasing atmospheric depth, the decrease of the flux at a constant electron number with increasing zenith an...

A growing number of social scientists fear that marriage may be on the rocks and few doubt that matrimony, as we have known it, has undergone a wrenching period of change in the past several decades. Andrew Cherlin, a leading sociologist of the family, speaks of "the de-institutionalization of marriage," conceding a point to conservative commentators who have argued that marriage and the family...

BACKGROUND Biomedical scientists need to access figures to validate research facts and to formulate or to test novel research hypotheses. However, figures are difficult to comprehend without associated text (e.g., figure legend and other reference text). We are developing automated systems to extract the relevant explanatory information along with figures extracted from full text articles. Such...

Although most philosophical accounts about model/world relations focus on structural mappings such as isomorphism, similarity has long been discussed as an alternative account. Despite its attractions, proponents of the similarity view have not provided detailed accounts of what it means that a model is similar to a realworld target system. This article gives the outlines of such an account, dr...