This study was undertaken to investigate the effect of aqueous extract Artemisia herba alba (Asteraceae) and procaine penicillin on healing induced defect ear cartilage. A total (25) female rats which used in this were distributed randomly into five treatment group(five animals per each). Under routine surgery, all had circular holes elastic cartilage their ears. All groups treated with local a...

Previous work showed that mice that had been thymectomized at 3 days of age tended, in later life, to develop a hyperplastic autoimmune gastritis and were also hypersusceptible to sarcogenesis by low dosages of 3-methylcholanthrene. In the present work, it was found that the hyperplastic autoimmune gastritis could be transferred with great effi ciency with spleen cells obtained from 3-mo-old do...

The zebrafish model organism was applied first in a metabolic study of icariin, baohuoside I, epimedin A and epimedin C, which are flavonoids in Herba Epimedii. Metabolites of these compounds in zebrafish after exposure for 24 h were identified by HPLC-ESI-MS, whereby the separation was performed with a Zorbax C-18 column using a gradient elution of 0.05% formic acid acetonitrile-0.05% formic a...

Since the observations of Kidder et al. (8) that 8-azaguanine selectively inhibits the development of three types of mouse neoplasms, many investi gators have examined the carcinostatic power of this compound on a variety of cancer tissues in different animal species. It has been found that 8-azaguanine is active against many additional malignant neoplasms (5, 6, 9, 10, 14, 16) but produces lit...

This paper describes the development of an HPLC-UV-MS method for quantitative determination of andrographolide and dehydroandrographolide in Andrographis Herba and establishment of its chromatographic fingerprint. The method was validated for linearity, limit of detection and quantification, inter- and intra-day precisions, repeatability, stability and recovery. All the validation results of qu...

The first report of a methylcholanthrene-in duced transplantable melanotic tumor in a Syrian golden hamster was published by Shubik and asso ciates (14). Spontaneous hamster melanomas have been reported by Fortner and Allen (1) and Greene (5). Shubik found that no metastases occurred even when the tumors attained a size of 4 cm. in diameter. Fortner and Allen, and Greene reported diffuse metast...

The pharmacokinetics and metabolism of ifosfamide was investigated in a group of 16 pediatrie patients (5 girls) aged 1-17 years. Each received a dose of 3 g/m2/day for up to 3 days by continuous infusion. Plasma and urine were collected, and concentrations of ifosfamide and its principal metabolites were determined by a quantitative high-performance thin layer chromatography method. During 3 d...