نتایج جستجو برای: aromatic

تعداد نتایج: 42254  

2010
Ildiko Pecsi Ibolya Leveles Veronika Harmat Beata G. Vertessy Judit Toth

Aromatic interactions are well-known players in molecular recognition but their catalytic role in biological systems is less documented. Here, we report that a conserved aromatic stacking interaction between dUTPase and its nucleotide substrate largely contributes to the stabilization of the associative type transition state of the nucleotide hydrolysis reaction. The effect of the aromatic stac...

Journal: :Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2004
Takashi Yokoyama Hirokazu Tsuji Takaomi Akamatsu Michio Zenki

The capillary electrophoretic behavior of 44 aromatic organic ions was investigated. The observed ionic radii (r(obs0)) for the aromatic organic ions were obtained from the electrophoretic mobilities of sodium tetraborate (pH 9.2), potassium tetraborate (pH 9.2), ammonium borate (pH 9.2), and trisodium phosphate (pH 11.7) buffers with zero ionic strength. The linear relationships between the r(...

Journal: :Organic & biomolecular chemistry 2015
Stephen R D George Thomas D H Frith Donald S Thomas Jason B Harper

A series of aromatic hydrocarbons were investigated so as to compare the reactivity of corannulene with planar aromatic hydrocarbons. Corannulene was found to be more reactive than benzene, naphthalene and triphenylene to Friedel-Crafts acylation whilst electrophilic aromatic bromination was also used to confirm that triphenylene was less reactive than corannulene and that pyrene, perylene and ...

Journal: :Nanomedicine 2016
Praful R Nair S A Karthick Kyle R Spinler Mohammad R Vakili Afsaneh Lavasanifar Dennis E Discher

AIM In order to improve the delivery of aromatic drugs by micellar assemblies, and particularly by long and flexible filomicelles, aromatic groups were integrated into the hydrophobic block of a degradable diblock copolymer. MATERIALS & METHODS Aromatic filomicelles were formed by self-directed assembly of amphiphilic diblock copolymer PEG-PBCL with suitable block ratios. Worm-like filomicell...

The effect of three organic aromatic salts - Phenyltrimethylammonium (PhTMAB), benzyltrimethylammonium (BzTMAB) and benzyltrimethylammonium (BzTEAB) bromides - on the micellization of sodium dodecylsulfate has been investigated by conductometric method. The critical micelle concentration (CMC) values were found to decrease with increase in the concentration of the aromatic ammonium salts. Therm...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2001
I Azumaya

Aromatic secondary amides such as benzanilide (1) exist in a trans-amide form both in the crystal and in the solution, whereas N-methylbenzanilide (2) exists in cis form in the crystal, and predominantly in a cis form in the solution. Similar cis conformational preferences were observed in aromatic N,N'-dimethylated ureas and guanidines, in which two aromatic rings are located face to face. The...

Journal: :Chemical biology & drug design 2018
Michal Brylinski

The ability to design and fine-tune non-covalent interactions between organic ligands and proteins is indispensable to rational drug development. Aromatic stacking has long been recognized as one of the key constituents of ligand-protein interfaces. In this communication, we employ a two-parameter geometric model to conduct a large-scale statistical analysis of aromatic contacts in the experime...

Journal: :Molecular pharmacology 1997
B L Roth M Shoham M S Choudhary N Khan

Several models of agonist binding to G protein-coupled 5-hydroxytryptamine [5-HT] (serotonin) receptors have highlighted the potential importance of highly conserved aromatic residues for ligand binding and agonist efficacy. In this study, we tested these models by constructing and characterizing a number of point mutations of conserved and nonconserved aromatic residues using the 5-HT2A recept...

2017
Lin Cheng Long Qian Guo-Sheng Wang Xiao-Mei Li Xiang-Pei Li

The goal of this study was to evaluate the potential relationship among polymorphisms of aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor, and rheumatoid arthritis (RA) susceptibility as well as the association among the polymorphisms of aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor, and their expression.We performed a hospital-based, case-control ...

Journal: :Physical chemistry chemical physics : PCCP 2013
Stijn Fias Paul Geerlings Paul Ayers Frank De Proft

The chemical importance of the linear response kernel from conceptual Density Functional Theory (DFT) is investigated for some σ and π aromatic and anti-aromatic systems. The effect of the ring size is studied by looking at some well known aromatic and anti-aromatic molecules of different sizes, showing that the linear response is capable of correctly classifying and quantifying the aromaticity...

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