The dissolution rate of glass fibers has been shown to be pH sensitive using in vitro lung fluid simulant models. The current study investigated whether there is a difference in phagosomal pH (ppH) between rat alveolar macrophages (AM) and rat nasal epithelial cells (RNEC) and whether such a difference would influence the dissolution of glass fibers. The ppH was measured in cultured AM and RNEC...

Siderite (FeCO3) is an important reduced phase iron mineral and end product of bacteria anaerobic respiration. This study addresses its dissolution behavior in the presence of the oxidant chromate, which is a common environmental contaminant. Macroscopic dissolution experiments combined with microscopic observations by atomic force microscopy show that at pH < 4.5 the dissolution rate with chro...

In this study, febantel was dissolved under increased temperature in a nonionic surfactant Lutrol L44® and subsequently mixed into an aqueous maltodextrin solution. After 8h under static conditions, coacervation or phase separation took place. (1)H NMR spectra and HPLC analysis showed that the upper phase contained mainly all febantel, while no febantel was detected in the lower phase. Fluoresc...

A correlation of the logarithmic values of the in vitro dissolution rate, G, and the apparent solubility, S, was evaluated in phosphate and ammonium acetate buffer at an initial pH of 7. The dissolution rates were determined with a newly designed and build miniaturized rotating disk equipment, as well as with a traditional rotating disk apparatus. The two apparatuses gave the same correlation p...

Surface carbonate sediments from sites on the Bahamas Bank with different seagrass densities were incubated across a range of O2 delivery rates, to study the controls on metabolic carbonate dissolution in these sediments. The results confirmed the 1:1 ratio between the rates of O2 consumption and carbonate dissolution, demonstrating that microbial respiration was the ratelimiting step in metabo...

For a two-phase (liquid-gas) two-component (water-hydrogen) system we discuss the formulation of the possible dissolution of hydrogen in the liquid phase. The problem is formulated as a set of nonlinear partial differential equations with complementary constraints and we show how Henry’s law fits in a phase diagram. Key-words: Porous media, two-phase flow, dissolution, nuclear waste underground...

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

For a two-phase (liquid-gas) two-component (water-hydrogen) system we discuss the formulation of the possible dissolution of hydrogen in the liquid phase. The problem is formulated as a set of nonlinear partial differential equations with complementary constraints and we show how Henry’s law fits in a phase diagram. Key-words: Porous media, two-phase flow, dissolution, nuclear waste underground...

A novel process for obtaining controlled morphologies in polymer blends is modeled numerically. Particles of one type of polymer are allowed to dissolve in a matrix of a dissimilar polymer. Prior to complete dissolution the blend is quenched into the two-phase region, such that phase separation takes place. The combination of the incomplete dissolution and the wavelength selection process assoc...

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the ...