Prostate cancer cells adhere to a tumor basement membrane, while secretory epithelial cells reside in a suprabasal cell compartment. Since tumor cells are derived from suprabasal epithelial cells, they experience de-novo substratum adhesion in the context of oncogenesis. We therefore analyzed whether cell-matrix adhesion could affect the protein expression and activity of the AR. In this study,...

Let G be a graph and V (G) be the vertex set of G. Let a1 ,. . . , ar be positive integers, m = ∑ r i=1 (ai−1)+1 and p = max{a1, . . . , ar}. The symbol G → {a1, . . . , ar} denotes that in every r-coloring of V (G) there exists a monochromatic ai-clique of color i for some i = 1, . . . , r. The vertex Folkman numbers F (a1, . . . , ar ; m − 1) = min{|V (G)| : G → (a1 . . . ar) and Km−1 6⊆ G} a...

Previous studies demonstrated an enhanced beta(2)-adrenoceptor (AR) responsiveness in animals susceptible to ventricular fibrillation (VF) that was eliminated by exercise training. The present study investigated the effects of endurance exercise training on beta(1)-AR and beta(2)-AR expression in dogs susceptible to VF. Myocardial ischemia was induced by a 2-min occlusion of the left circumflex...

Heat shock protein (hsp) 70-1 (hsp70-1) is overexpressed in human prostate cancer cells and may play important roles in prostate cancer resistance to conventional therapies. The purpose of this study was to investigate whether androgen receptor (AR) and its signaling regulate hsp70-1 expression. Several lines of AR-positive (LNCaP, LAPC-4, and 22Rv1) and -negative (PC-3, DU145, WPE1-NB14 and WP...

The mechanisms underlying the blunted contractile response to -adrenergic receptor ( -AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to -AR subtype–specific regulation of L-type Ca channels. We evaluated the impact of HF induced by pacing tachycardia on -AR regulation of L-type Ca channels in a canine model. To evaluate changes in the relative subcellu...

This study examined the effects of transfer of a 2.4-Mbp region of rat chromosome 1 (RNO1) from Brown Norway (BN) into fawn-hooded hypertensive (FHH) rats on autoregulation (AR) of cerebral blood flow (CBF) and the myogenic response of middle cerebral arteries (MCAs). AR of CBF was poor in FHH and FHH.1(BN) AR(-) congenic strains that excluded the critical 2.4-Mbp region. In contrast, AR was re...

  Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, 55 cases of invasive ductal breast carcinoma were examined using a monoclonal antibody against AR on...

The androgen receptor (AR) is not only a ligand-dependent transcription factor, but also functions as a licensing factor, a component of DNA replication, which is degraded during mitosis. Furthermore, the deregulation of AR activity is involved in the initiation of prostate cancer and contributes to castration resistant prostate cancer (CRPC). While AR degradation is known to occur primarily th...

The vascular response to adenosine and its analogs is mediated by four adenosine receptors (ARs), namely, A(1), A(2A), A(2B), and A(3). A(2A)ARs and/or A(2B)ARs are involved in adenosine-mediated vascular relaxation of coronary and aortic beds. However, the role of A(1)ARs in the regulation of vascular tone is less well substantiated. The aim of this study was to determine the role of A(1)ARs i...

LetR be a commutative ring and let n,m be two positive integers. Let AR(n,m) := R[x11, . . . , x1m, . . . , xn1, . . . , xnm] be the polynomial ring in the commuting independent variables x11, . . . , x1m, . . . , xn1, . . . , xnm with coefficients in R. The symmetric group on n letters Sn acts on AR(n,m) by means of σ(xij) = xσ(i) j for all σ ∈ Sn and i = 1, . . . , n ; j = 1, . . . , m. Let u...