BACKGROUND Prior research suggests that both social networks and parent drug use influence individual drug use among adolescents and that peers continue to influence drug use among adults. This analysis aims to determine whether parent drug use during childhood is associated with having drug-using networks in adulthood after adjusting for individual adult drug use. METHODS 650 young adult dru...

One of the most frequently reported, yet understudied, motivations for non-suicidal self-injury (NSSI) involves automatic positive reinforcement (APR), wherein sensations arising from NSSI reinforce and promote the behavior. The current study used experience sampling methodology with a clinical sample of self-injuring adolescents (N=30) over a 2-week period during which the adolescents reported...

PURPOSE State-based Medicaid programs have begun using All Patient Refined-Diagnosis-Related Groups (APR-DRGs) to determine hospital reimbursement rates. Medicaid provides coverage for 45% of childhood cancer admissions. This study aimed to examine how well APR-DRGs reflect admission costs for childhood cancer chemotherapy to inform clinicians, hospitals, and policymakers in the wake of policy ...

INTRODUCTION The American Heart Association established 7 cardiovascular health metrics as targets for promoting healthier lives. Cardiovascular health has been hypothesized to play a role in individuals' perception of quality of life; however, previous studies have mostly assessed the effect of cardiovascular risk factors on quality of life. METHODS Data were from the 2013 Behavioral Risk Fa...

Cardiopulmonary bypass (CPB) elicits derangements to the formed elements of blood because of the physical stresses of extracorporeal flow. Methods of reducing the impact of CPB include circuit surface modification and pharmacological supplementation. The purpose of this study was to examine the effects of aprotinin in combination with surface modification during simulated CPB. Fresh whole bovin...

1. USPSTF Backs Aspirin for Primary Prevention (Apr 11/16) 2. Vitamin C may kill cancer cells in KRAS-mutant colorectal cancer (Apr 19/16) 3. Trastuzumab Plus Lapatinib Active in Refractory HER2+ Metastatic Colorectal Cancer (Apr 21/16) 4. Numerous Frontline CRC Options Allow Individualized Approach (Apr 23/16) 5. Taking low-dose aspirin during cancer treatment cuts deaths (May 11/16) 6. Blood ...

An improved PCR-based subtractive hybridization strategy was used to clone apoptosis-related genes induced by all-trans retinoic acid (ATRA) from human promyelocytic leukemia cell line HL-60 cells. The protocol used the cap-finder method, long-distance PCR, streptavidin magnetic bead-mediated subtraction and spin column chromatography. Twenty-seven clones related to apoptosis were identified by...

To compare the difference between the extralevator abdominoperineal excision (ELAPE) and abdominal perineal resection (APR) in circum ferencial resection margin (CRM) positive rate, intraoperative perforation (IOP) the incidence of postoperative wound infection, incision infection reoperation rate, surgical indications, operation time, hemorrhage volume, the recurrence rate, postoperative quali...

It is not known whether acute brain injury results in a systemic acute phase response (APR) or whether an APR influences outcome after an insult to the CNS. The present study sought to establish whether brain injury elicits a systemic or local APR. The expression of acute phase protein (APP) mRNA in liver and brain tissues was measured by Taqman reverse transcriptase-polymerase chain reaction a...

Members of the C/EBP (CCAAT/enhancer binding protein) family of transcription factors play important roles in mediating the acute-phase response (APR), an inflammatory process resulting from infection and/or tissue damage. Among the C/EBP family of proteins, C/EBPbeta and -delta were thought to be the primary mediators of the APR. The function of C/EBPalpha in the APR has not been fully charact...