Bullous ichthyosiform erythroderma (BIE) is a rare disorder of keratinization (mutations in either keratin 1 or 10). It typically presents with fragile skin, which gives way to gradual evolutionof hyperkeratosis. Flaccid blisters, peeling, and superficial erosions at sites of minor trauma or friction are apparent within the first few hours of life. Yellow-brown, waxy, ridged or corrugated...

leigh syndrome is a severe progressive neurodegenerative disorder with different clinical presentationsthat usually becomes apparent in the first year of life and rarely in late childhood and elderly years. it is causedby failure of mitochondrial respiratory chain and often results in regression of both mental and motor skills and might even lead to death. in some of the inherited neurodegenera...

There are several debates around why Socrates executed but none of them has explained why he executed at seventy. I think Socratic hubris can explain it. In fact, if we refer to “earlier Socrates” dialogues that cover life of Socrates from youth to seventy years, it is obvious that Socrates on effort to find and present a good life appealed to speech and used it to cross-examine Athenians. Howe...

Apparent actions We assume that a passive observer perceives a sequence S of sensor values (s1, ..., sT ) with T ∈ N. At each instance t of the sequence, the observer has a memory or knowledge state mt which gives us a second sequence M = (m1, ...,mT ). The memory state of the agent might contain models of the observations or not. In the course of a sequence S there is an apparent action for ob...