Okra (A.esculentus) is an antidiabetic plant that it's beneficial effects on ovarian dysfunction in diabetes condition has not been clarified. The present study was designed to examine the effect of Okra powder on serum oxidant/antioxidant status, ovarian structure and expression of apoptotic/antiapoptotic related genes in ovary of experimentally induced high fat diet diabetic rats. Diabetes wa...

Background and Aims: Benzopyrones are a group of compounds including coumarins and chromenes. Chromenes have a heterocyclic structure with gamma benzopyran which has anticancer activities. In this investigation we studied the effect of 4 new derivatives of chromene compounds on the human acute lymphoblastic leukemia cell line MOLT4. Materials and Methods: The structure of the new compound was ...

To study the molecular mechanisms by which drug resistance develops, we compared DU145 humanprostate cancer cells with a subline selected for resistance to camptothecin. Differences in gene expression level were assessed by hybridizing the two cell types against each other using quadruplicate "Oncochip" cDNA microarrays that included 1648 cancer-related genes. Expression levels differing by a f...

Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of water extract senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231).Methods: The MTT assay was to assess proliferation. expression apoptosis-related genes assessed by quantitative real-time PCR.Results: ASF treatme...

PURPOSE Inhibition of the apoptosis cascade is an important cause of therapy resistance in diffuse large B-cell lymphomas (DLBCL). In this study, we investigated possible mechanisms and expression levels of apoptosis-related genes in the apoptosis pathway that may be responsible for differences in chemotherapy sensitivity between DLBCL patients. EXPERIMENTAL DESIGN Twenty-eight DLBCL patient ...

The improved peri-implant bone response demonstrated when utilizing the platform-switching concept may result from reduced levels of metal ions released implant–abutment surfaces to surrounding tissues. These corrosion products play a major role in crestal remodeling around dental implants. This study evaluated effect different couplings (platform-matched vs. platform-switched) on osteoblasts’ ...

Objective(s):  Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. Because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), in present study we studied the apoptosis in T lymphocytes from Iranian SLE patientsat protein and gene expression levels for some molecules which are involved in apopt...

Surgical resection coupled with adjuvant radiotherapy and/or doxorubicin based chemotherapy are the mainstays of synovial sarcoma (SS) treatment. Although effective as a SS adjuvant, the proposed mechanism of action of doxorubicin remains controversial. Current opinion supports DNA damage-induced apoptosis. This in vitro study used cDNA gene expression profiling to investigate whether apoptosis...

Chronic inflammation plays a key role in the development and progression of several chronic diseases. Inhibiting inflammatory cascade, thereby minimising damage caused by mediators, can be one strategies disease management. In addition, is closely related to apoptosis, cause apoptosis. Lemon peel has been reported have antioxidant anti-inflammatory biological activities. This study aimed invest...