A role for apolipoprotein E is implicated in regeneration of synaptic circuitry after neural injury. The in vitro mouse organotypic hippocampal slice culture system shows Timm’s stained mossy fiber sprouting into the dentate gyrus molecular layer in response to deafferentation of the entorhinal cortex. We show that cultures derived from apolipoprotein E knockout mice are defective in this sprou...

OBJECTIVES The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline. METHODS Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline ...

Genome wide association studies for complex diseases are typically followed by more focused characterization of the identified genetic region. We propose a latent class model to evaluate a candidate region with several measured markers using observations on families. The main goal is to estimate linkage disequilibrium (LD) between the observed markers and the putative true but unobserved diseas...

+ United Graduate School of Agricultural Sciences, Kagoshima University, Korimoto + ,+ ,., Kagoshima 23* **0/, Japan Department of Clinical Laboratory Medicine, School of Medicine, University of the Ryukyus Hospital, Uehara ,*1, Nishihara, Okinawa 3**,+/, Japan Department of Bioproduction, Faculty of Agriculture, University of the Ryukyus, Senbaru +, Nishihara, Okinawa 3**,+-, Japan Department ...

The study aim was to estimate the genetic contribution to individual differences in different forms of memory in a large family-based group of older adults. As part of the Late Onset Alzheimer's Disease Family Study, 899 persons (277 with Alzheimer's disease, 622 unaffected) from 325 families completed a battery of memory tests from which previously established composite measures of episodic me...

Apolipoprotein mRNA Translation and PostTranslational Modification Co-translational processing of preapolipoproteins Post-translational processing of mammalian apolipoproteins a. ApoA-I b. ApoA-I1 Post-translational modification of apolipoproteins ApB-48 synthesis in the small intestine The Apolipoprotein Genes Chromosomal localization and linkage analysis a. ApoA-I/C -III/A-IV b. ApoE/C-I and ...

The APOE epsilon4 allele is a risk factor for late-life pathological changes that is also associated with anatomical and functional brain changes in middle-aged and elderly healthy subjects. We investigated structural and functional effects of the APOE polymorphism in 18 young healthy APOE epsilon4-carriers and 18 matched noncarriers (age range: 20-35 years). Brain activity was studied both at ...