Background: Aplastic anemia is a rare but serious disorder. More than 70% cases of anemia are idiopathic. This study was conducted to find out the possible etiological factors in our set up. Methodology: This descriptive study was carried out in Department of Medicine, Khyber Teaching Hospital, Peshawar from January, 2005 to December, 2009. One hundred patients with acquired aplastic anemia wer...

We have analyzed natural killer (NK) cells in 43 patients with severe aplastic anemia, using cytotoxicity assays and microfluorometry with monoclonal antibodies, prior to and after treatment with antithymocyte globulin (ATG). Before treatment, natural killer cell activity (NKa) in both peripheral blood and bone marrow was markedly decreased in 76% of patients as compared with normal controls. A...

Aplastic anemia is associated with quantitative and functional abnormalities in the hematopoietic stem cell compartment. Currently, one of the most primitive human hematopoietic progenitor cells that can be functionally assayed in vitro is the long-term culture-initiating cell (LTC-IC). This assay identifies primitive cells that are capable of producing colonies after five weeks of long-term cu...

BACKGROUND Paroxysmal nocturnal hemoglobinuria is an acquired chronic hemolytic anemia, which often manifests as peripheral blood cytopenias and thrombosis. OBJECTIVE The aim of this study is to describe a Brazilian population of paroxysmal nocturnal hemoglobinuria patients. METHODS One hundred and three paroxysmal nocturnal hemoglobinuria cases were retrospectively reviewed and the clinica...

The clinical spectrum of infections caused by non-typhoid Salmonella spp. includes gastroenteritis, enteric fever, bacteremia, and extraintestinal localized complications, especially in immunocompromised hosts. Here we report a patient with severe aplastic anemia developing left iliopsoas abscess caused by non-typhoid Salmonella (NTS), which was successfully treated by prolonged antibiotic trea...

Hepatitis associated aplastic anemia (HAAA) is a well documented entity. The disorder mainly affects children and young adults. Pancytopenia is usually noted within 2-6 months time after an acute attack of hepatitis. Most cases have been described in association with hepatitis A or hepatitis C Virus. The report describes, an unusual case of acquired aplastic anemia in a patient with hemophilia ...

This study was undertaken primarily to test the hypothesis that mitochondrial DNA (mtDNA) mutations may be associated with aplastic anemia. Complete mtDNA nucleotide sequence was analyzed in nine and eight bone marrow specimens from Korean patients with aplastic anemia and healthy individuals, respectively. We found a large number of polymorphisms as well as apparent new mutations in both patie...

We performed a phase I/Il study of the administration of recombinant human granulocyte-macrophage colonystimulating factor (GM-CSF) to patients with aplastic anemia or myelodysplastic syndrome. Doses ranging from 15 to 480 .tg/m2 were administered as a one-hour or fourhour intravenous infusion daily for 7 days or as a 1 2-hour infusion for 1 4 days. Temporary improvements were seen in granulocy...