نتایج جستجو برای: apl

تعداد نتایج: 3971  

2011
Anna Falanga Laura Russo Carmen J Tartari

Acute promyelocytic leukemia (APL) is a distinct subtype of myeloid leukemia characterized by t(15;17) chromosomal translocation, which involves the retinoic acid receptor-alpha (RAR-alpha). APL typically presents with a life-threatening hemorrhagic diathesis. Before the introduction of all-trans retinoic acid (ATRA) for the cure of APL, fatal hemorrhages due, at least in part, to the APL-assoc...

Journal: :Blood 1996
J C Otero S Santillana G Fereyros

A high frequency (24%) of acute promyelocytic leukemia (APL) was noted among acute myelocytic leukemia (AML) cases at the Los Angeles County-University of Southern California (LAC-USC) Medical Center, in comparison with the expected frequency of 5% to 15%. Because of the high proportion of Latinos in this center, we questioned if APL is more common in this ethnic group. The proportion of APL am...

2016
Federica Sorà Patrizia Chiusolo Luca Laurenti Francesco Autore Sabrina Giammarco Simona Sica

Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with thrombolysis for PE and heparin. APL has been processed with a combination of ...

Journal: :The Journal of clinical investigation 2011
Raajit K Rampal Ross L Levine

Acute promyelocytic leukemia (APL) is a malignancy of the bone marrow, in which there is a deficiency of myeloid cells and an excess of immature cells called promyelocytes. APL is most commonly caused by a translocation (15:17) and expression of the promyelocytic leukemia and the retinoic receptor α (PML-RARA) fusion product; however, the events that cooperate with PML-RARA in APL pathogenesis ...

Journal: :journal of dental research, dental clinics, dental prospects 0
sepideh banava azad university, head of dental materail department kaveh najibfard 2 university of texas health science center at san antonio, tx, usa franklin garcia godoy mohammad ali saghiri mohammad hossein ghahremani bioscience research center, college of dentistry, the university of tennessee health science center, memphis, tn, usa naser ostad department of toxicology and pharmacology, faculty of pharmacy, and pharmaceutical sciences research centre, tehran university of medical sciences, tehran

background and aims. the aim of this study was to evaluate the effect of dilution and curing methods of an etch-and-rinse adhesive and a self-etching primer from the same manufacturer at early exposure time on cytotoxicity of primary hu-man gingival fibroblasts. materials and methods. primary human gingival fibroblasts were exposed to different dilutions of adper single bond (asb) and adper pro...

Journal: :Cancers 2023

Tailored treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has revolutionized the outcome of acute promyelocytic leukemia (APL) from a uniformly fatal disease to one most curable malignant diseases in humans. Due its high efficacy, ATO/ATRA is standard first-line therapy younger adult, non-high-risk APL patients. However, early death still major issue APL, particularly ol...

Journal: :Lupus 1999
E E Gharavi H Chaimovich E Cucurull C M Celli H Tang W A Wilson A E Gharavi

We previously induced pathogenic antibodies against anionic phospholipids (PL) in experimental animals by immunization with lipid-free purified human beta2glycoprotein I (beta2GPI). We hypothesized that antiphospholipid antibodies (aPL) are induced by in vivo binding of foreign beta2GPI to self-PL, thus forming an immunogenic complex against which aPL antibodies are produced. If this hypothesis...

2017
Anand P. Jillella Martha L. Arellano Leonard T. Heffner Manila Gaddh Amelia A. Langston Hanna J. Khoury Abhishek Mangoankar Vamsi K. Kota

Acute promyelocytic leukemia (APL) is a hyper-acute leukemia and presents with cytopenias and disseminated intravascular coagulation. Jehovah’s Witnesses with APL offer a unique challenge during induction by refusing transfusion and pose a difficult challenge in this curable disease. Our focus over the last 8 years has been decreasing early deaths in APL in both academic and community centers. ...

2012
Mary Wiese Adam Antebi Hui Zheng

BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of β-amyloid plaques composed primarily of the amyloid-β peptide, a cleavage product of amyloid precursor protein (APP). While mutations in APP lead to the development of Familial Alzheimer's Disease (FAD), sporadic AD has only one clear genetic modifier: the ε4 allele of the apolipoprotein E (Ap...

Journal: :Blood 1993
J D Oosting R H Derksen I W Bobbink T M Hackeng B N Bouma P G de Groot

Despite many studies on the pathophysiology of antiphospholipid antibodies (aPL), the mechanism by which aPL causes thrombosis has not been established. We have tried to elucidate the paradox between the prolongation of the clotting time of phospholipid-dependent coagulation tests in vitro and the occurrence of thrombosis in vivo. The effect on endothelial cell-mediated prothrombinase activity ...

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