نتایج جستجو برای: apaf1

تعداد نتایج: 548  

Journal: :The Journal of Cell Biology 2004
Clare L. Scott Martin Schuler Vanessa S. Marsden Alex Egle Marc Pellegrini Dobrila Nesic Steve Gerondakis Stephen L. Nutt Douglas R. Green Andreas Strasser

Based on experiments with cultured fibroblasts, the apoptosis regulators caspase-9 and Apaf-1 are hypothesized to function as tumor suppressors. To investigate their in vivo role in lymphomagenesis, an IgH enhancer-driven c-myc transgene was crossed onto Apaf-1(-/-) and caspase-9(-/-) mice. Due to perinatal lethality, Emu-myc transgenic Apaf-1(-/-) or caspase-9(-/-) fetal liver cells were used ...

Journal: :International journal of biological macromolecules 2015
Raheleh Shakeri Saman Hosseinkhani Marek J Los Jamshid Davoodi Mayur V Jain Artur Cieślar-Pobuda Mehrdad Rafat Sussan Kaboudanian Ardestani

Apaf-1, the key element of apoptotic mitochondrial pathway, normally exists in an auto-inhibited form inside the cytosol. WRD-domain of Apaf-1 has a critical role in the preservation of auto-inhibited form; however the underlying mechanism is unclear. It seems the salt bridges between WRD and NOD domains are involved in maintaining the inactive conformation of Apaf-1. At the present study, we h...

Journal: :The Journal of Cell Biology 2004
Kevin M. Wright Michael W. Linhoff Patrick Ryan Potts Mohanish Deshmukh

Despite the potential of the inhibitor of apoptosis proteins (IAPs) to block cytochrome c-dependent caspase activation, the critical function of IAPs in regulating mammalian apoptosis remains unclear. We report that the ability of endogenous IAPs to effectively regulate caspase activation depends on the differentiation state of the cell. Despite being expressed at equivalent levels, endogenous ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Qi Hu Di Wu Wen Chen Zhen Yan Chuangye Yan Tianxi He Qionglin Liang Yigong Shi

Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that the previously reported 1:1 interaction between Apaf-1 caspase recruitm...

Journal: :Brain research 2000
D W Walke J I Morgan

Apaf-1 is a mammalian homolog of CED-4 that regulates cell death by participating in a ternary complex with cytochrome c, and procaspase-9. In the case of CED-4, two splice variants exist. The smaller (CED-4S) is proapoptotic while the larger (CED-4L) contains a short in-frame insert and is anti-apoptotic. We cloned a murine variant of apaf-1, termed apaf-1L, which contains an eleven amino acid...

2016
Chi Lam Au Yeung Ngai-Na Co Tetsushi Tsuruga Tsz-Lun Yeung Suet-Ying Kwan Cecilia S Leung Yong Li Edward S Lu Kenny Kwan Kwong-Kwok Wong Rosemarie Schmandt Karen H Lu Samuel C Mok

Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that modulate ovarian cancer growth have not been characterized. Here, using next-generation sequencing technology, we identify significantly higher levels of microRNA-21 (miR21) isomiRNAs in exosomes and tissue lysates isolated from cancer-asso...

Journal: :Cell structure and function 2003
Hiroki Yoshida

Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of C. elegans, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistan...

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