The present study was carried out to investigate the anxiolytic activity of Ipomoea aquatica leaves. The shade dried leaves were extracted successively with petroleum ether and methanol: acetone (MAE-IA). The total flavonoids contents were determined as 200 mg/kg of dried plant material. The anxiolytic activity of MAE-IA was evaluated using elevated plus maze, light: dark apparatus, hole board ...

objective: the present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of solanum sisymbriifolium lam. (family: solanaceae). materials and methods: the analgesic activity was measured by acetic acid-induced writhing inhibition test. the neuropharmacological activities were evaluated using ho...

Anxiety disorders have become the number one mental health issue in developed countries. The of people living with anxiety and depressive rose significantly because COVID-19 pandemic. Although generally considered as safe effective, currently available anxiolytic therapy is responsible for numerous side effects addiction. Therefore, there an imperious demand discovering more efficient cheaper n...

Anxiety disorders have become the number one mental health issue in developed countries. The of people living with anxiety and depressive rose significantly because COVID-19 pandemic. Although generally considered as safe effective, currently available anxiolytic therapy is responsible for numerous side effects addiction. Therefore, there an imperious demand discovering more efficient cheaper n...

BACKGROUND The placebo effect in relieving negative emotion arousal is poorly understood. AIMS We examined whether placebo expectation established with noise stimuli could have a transferable anxiolytic effect on negative emotion arousal. METHODS In Experiment 1, noise intensity was surreptitiously lowered during placebo condition in the preconditioning phase to reinforce placebo expectatio...

Phlegmatic people dislike taking benzodiazepine drugs. In those with low'anxiety traits benzodiazepines are dysphoric and may paradoxically increase anxiety.' In normal subjects benzodiazepines improve performance under experimental stress but worsen it under conditions of low stress.2 Benzodiazepines relieve preoperative anxiety in patients with high anticipatory anxiety but not in those with ...

OBJECTIVE The aim of the present study was to evaluate the anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A in comparison with diazepam. MATERIALS AND METHODS We evaluated the ultrasonic distress emission in both sexes of neonatal rat pups (which seems to be a sensitive indicator of the rat emotional reactivity and represents a valuable tool to screen compounds with...

UNLABELLED INTRODUSTION: Sibutramine has been described as a drug recommended for treatment of obesity, since it has the ability to inhibit the reuptake of serotonin and noradrenaline in the central nervous system, thereby increasing energy expenditure. OBJECTIVE Investigate the anxiogenic and anxiolytic effects of acute and chronic treatment with sibutramine in rats submitted to the task of ...

At present, the effects of quercetin liposome on anxiolytic activity and cognitive function are unclearly known. In this study, male Wistar rats were administered quercetin liposome via intranasal route once daily continually for 4 weeks. The anxiolytic activity and cognitive enhancing effect were determined after single administration, 1, 2, 3 and 4 weeks of treatment using elevated plus maze ...