The ever-evolving research in the field of antitubercular agents has led to identification several new potential drug classes. Among them, 5-phenyl-furan-2-carboxylic acids have emerged as innovative therapeutics, targeting iron acquisition mycobacterial species. In our efforts characterize molecular interactions between these compounds and their protein target (MbtI from M. tuberculosis) by me...

Drugs for tuberculosis are inadequate to address the many inherent and emerging challenges of treatment. In the past decade, ten compounds have progressed into the clinical development pipeline, including six new compounds specifically developed for tuberculosis. Despite this progress, the global drug pipeline for tuberculosis is still insufficient to address the unmet needs of treatment. Addit...

Tubercular esophagocutaneous fistula is a rare entity with only about five cases reported so far. To our best knowledge we herein report first case of tubercular esophagocutaneous fistula in neck of a child with a long tract which responded well to antitubercular treatment.

Isolated sternal involvement in tuberculosis is rare. Very few case reports are available in literature even from the countries where tuberculosis is endemic. We are reporting a case of 32-year-old female who presented to us with a pus discharging sinus over manubrium sterni with no other systemic features of tuberculosis. Sinus tract was excised and biopsy confirmed tuberculosis. Patient recei...

Rob Aarnoutse, Carolien Ruesen, Erlina Burhan, Reinout van Crevel, Rovina Ruslami ‹Radboud University Medical Centre, Department of Pharmacy, Nijmegen, The Netherlands; Radboud University Medical Centre, Department of Internal Medicine, Nijmegen, The Netherlands; University of Indonesia, Faculty of Medicine, Department of Pulmonology and Respiratory Medicine, Jakarta, Indonesia; University of P...

A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted by the introduction of a methoxy group ortho to the acetylenic group. Most compounds were more active against non-replicating than replicating cultures of Mycobacterium tuberc...