Antibodies that reacted with plasma membranes of human eye muscle but showed no binding to plasma membranes of human skeletal muscle were identified in serum of patients with Graves' ophthalmopathy. Rabbit antithyroglobulin serum at a dilution of 1 X 10(-3) to 20 X 10(-3) had no effect on the binding of these antibodies to eye muscle membrane antigens. There was no correlation between antihuman...

Antibodies interact with the follicular cell, colloid, or thyroglobulin antigens and activate the complement cascade and cell-mediated cytotoxicity. The progressive destruction of follicles and secondary fibrosis eventually leads to a failure of thyroid hormone production. More than 60 or 70% of the thyroid tissue needs to be destroyed before we see changes in laboratory measures of thyroid fun...

The presence of antithyroid antibodies (antithyroglobulin and antimicrosomal) in serum of patients with Down's syndrome and their respective mothers were studied based on data from the literature, showing a possible correlation between the presence of these antibodies in the serum of mothers and the birth of mongoloid children. Antithyroid antibodies were studied in 40 patients with Down's synd...

background: mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. antineutrophil cytoplasmic antibodies (anca's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculit...

Destruction-induced thyrotoxicosis includes various painful diseases such as subacute granulomatous thyroiditis, acute exacerbation of chronic thyroiditis and acute suppurative thyroiditis. In contrast, the clinically painless form of destruction-induced thyrotoxicosis is almost exclusively restricted to painless or silent thyroiditis. We report what we believe to be a case of acute exacerbatio...

To the Editor: High doses of iodine-131 (131I) are commonly used in patients with differentiated thyroid cancer (DTC) after total or subtotal thyroidectomy, in order to ablate the remaining cancer or normal thyroid tissue [1]. Whole body scan performed after about 5 days can visualize possible metastatic lesions [2] and may also show the stomach, salivary glands, the breasts expressing sodium i...

patients with malignancy are at higher risk of thrombotic complications due to the hypercoagulability state. our objective in this study was to assess the serum concentrations of homocysteine, anti phospholipid antibodies, and anti cardiolipin in patients with benign and malignant breast tumors and study the effect of chemotherapy on the serum levels of these markers. a case control study was c...

recurrent abortion is a critical problem in which many factors play a crucial role such as anticordiolipin antibody and antiphospholipid antibody. this study was conducted to evaluate the frequency of anticardiolipin antibody and antiphospholipid antibody in pregnancy failures in women with the history of recurrent pregnancy loss. in 154 women with the history of two or more recurrent pregnancy...

background: celiac disease is one of the malabsorption syndromes leads to growth and development retardation in children. there is no test lonely can definitely diagnose celiac; however, the collection of clinical findings, serologic tests, intestinal biopsy, and response to treatment may diagnose it. although diagnostic value is variable in different studies, they are used a non-invasive and a...