INTRODUCTION In mental healthcare, one area of major concern identified by health information systems is variability in antipsychotic prescribing. While most studies have investigated patient- and prescriber-related factors as possible reasons for such variability, no studies have investigated facility-level characteristics. The present study ascertained whether staffing level is associated wit...

BACKGROUND Serious safety concerns related to the use of antipsychotics have not decreased the prescribing of these agents to nursing home (NH) residents. We assessed the extent to which resident clinical characteristics and institutional prescribing practice were associated with antipsychotic prescribing. METHODS Antipsychotic prescribing was assessed for a nationwide, cross-sectional popula...

This systematic review assesses the effectiveness of antipsychotic medication for improving core psychopathology and behavioral symptoms of anorexia nervosa. The Cochrane Depression, Anxiety and Neurosis Group Trials Register, reference lists of retrieved studies and conference abstracts were searched. Four randomized controlled trials comparing typical or atypical antipsychotic medication to o...

Risperidone is an atypical antipsychotic with broad spectrum of antipsychotic activity and lower potential for extrapyramidal side effects at therapeutic doses. This case report illustrates the development of tardive dyskinesia with therapeutic dose of risperidone in a paranoid schizophrenic patient who was not on any antipsychotic medication previously.

Condensation of o-phenylenediamine with isatine in refluxing glacial acetic acid gives indolo[2,3-b] quinoxaline. This moiety further condensed with n’-(n-Halo aloxy)-3,4-dihydro carbostyril in refluxing acetonitrile using NaI,K2CO3 and TBAB as catalyst gave us desire product. Series of all six analogs are taken for their antibacterial and antipsychotic activity. The entire tested compound show...

BACKGROUND Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially mimicked the appetite-stimulating and weight-inducing effects found in the clinical setting. Antipsychotic-induced effects on serum lipids are also inconsistent in rats, but in...

OBJECTIVE To investigate the executive function among adolescents with antipsychotic-treated schizophrenia in Child and Adolescent Outpatient Clinic at Cipto Mangunkusumo General Hospital, Jakarta. METHODS This was a cross sectional study with control group. Case was defined as adolescents with antipsychotic-treated schizophrenia without any mental retardation or other physical illnesses (n=4...

OBJECTIVES To examine associations between exposure to various subgroups of antipsychotic drugs and risk of hip fracture in older adults. DESIGN Nationwide cohort study. SETTING Norway, 2005-2010. PARTICIPANTS Everyone living in Norway born before 1945 (N = 906,422). MEASUREMENTS Information was obtained on all prescriptions of antipsychotic drugs dispensed from 2004 to 2010 (Norwegian ...

BACKGROUND Only three observational studies investigated whether exposure to antipsychotics is associated with an increased risk of pulmonary embolism, with conflicting results. This study was therefore carried out to establish the risk of pulmonary embolism associated with antipsychotic drugs, and to ascertain the risk associated with first- and second-generation antipsychotic drugs, and with ...

BACKGROUND The second-generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation, which may be associated with the use of SGAs. This study aims to review published reports of patients with schizophrenia and antipsychotic drug-associated DKA, focusing on the effective man...