Purpose: BackgroundIschemia reperfusion(IR) increases lactate.No one has examined if cardiac-specific coronary sinus lactate(CSL)can be reduced with prior cytoprotective heat shock protein 70(hsp70i) induction. We previous demonstrated improved IR in vivo inducted hsp70i.Geranylgeranylacetone(GGA), an hsp70i inducer, never been administered IV preischemically. Interventions to decrease CSL may ...

determination of pre-hospital delay time of patients with acute myocardial infarction and seeking ways of speeding up the time for reperfusion is an important factor to lower mortality in these patients. this is a cross-sectional study to determine pre-hospital delay time, its components, and related causes and conditions, obtained in 375 patients with prolonged chest pain referred to four hosp...

background: during the detorsion of a torsioned ovary, oxidant agents are released and melatonin as an antioxidant can reduce ischemia. we studied the histopathological changes after using melatonin on experimental torsioned ovary in cat. objective: the aim of this experimental study was to investigate the effects of melatonin on histopathological changes in torsion – detorsion injury in cat ov...

Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease that caused by the sudden rupture of blood vessels inside brain and intervention reperfusion to brain, resulting in severe cerebral injury. Autophagy has been reported be involved occurrence progression CIS. Betulinic acid (BA) a pentacyclic triterpene mainly extracted from birch bark. Studies have shown neuroprotective effects ...

Evaluation and treatment of acute ischemic stroke has undergone significant advancement since the 1990s, when systemic reperfusion with intravenous alteplase became first approved method for achieving reperfusion. Until recently, 4.5 h after onset appeared to be maximum time window in which positive results from thrombolysis can achieved. However, advent advanced imaging modalities, including m...

conclusions the results suggest the important role of the antioxidant system potentiation in the prevention of myocardial damage. results cell degenerative changes, pyknotic nuclei, contraction bands, edema, and loosening of collagen in between muscle fibers were observed during ischemia-reperfusion. myocardial architecture and cellular morphology were recovered in co-administration groups, esp...

Objective(s):To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods:Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypo...

introduction: during kidney and other organ's transplantation, the organ to be transplanted, must inevitably remain out of the body with little or no blood perfusion at all, for long period of time (ischemia). this causes the release of oxygen free radicals (ofr). reperfusion (reintroduction of blood flow) will further exacerbate the initial damage caused by the ischemic insult and may result i...

Aim: Our aim was to investigate expression level of VEGF in tuba uterine ovarian ischemia-reperfusion (I/R) by immunohistochemical techniques. Material and Methods: 30 Sprague Dawley female rats were categorized into three groups. Sham group: The abdomen opened closed without any treatment. Ischemia (I) 1-hour ischemia allowed create ischemic injury. Ischemia-reperfusion then 3-hour reperfusion...

Objective: The present study investigated the effects of a local Thai vegetable, Tiliacora triandra (Colebr.) Diels, also known as Yanang, against cerebral ischemia/reperfusion injury in mice. Materials and Methods: Thirty male ICR mice were divided into three experimental groups of BLCCAO + 10% Tween 80, BLCCAO + T. triandra 300 mg/kg, and BLCCAO + T. triandra 600 mg/kg. Cerebral ischemia/repe...