Objective: The aim of this in vitro study was to compare the antimicrobial effects of photodynamic antimicrobial chemotherapy (PACT), an ordinary antiseptic (chlorhexidini digluconas), and an antibiotic therapy (bacitracinum zincicum and neomycini sulfas) in vitro. Background: Photodynamic therapy (PDT) is an area of great interest for its potential use as an antimicrobial therapy. It is curren...

The oral cavity is colonized by a large number and highly diversified communities of micro-organisms. Bacterial biofilm present on tooth or root surface is a major cause of gingivitis and periodontitis. Chemical antimicrobial agents are widely used in prophylactic and therapeutic regimens for dental plaque related diseases, which are among the most common human infections. As these agents are d...

Multidrug resistance of pathogenic microflora is a serious threat to the modern community looking for new approaches treating superinfections. In this sense, antimicrobial photodynamic therapy (aPDT) an effective and safe technique considered be promising alternative or important supplement traditional clinically applied methods inactivating antibiotic resistant pathogens. Macroheterocyclic pho...

We review the recent literature concerning the efficiency of antimicrobial photodynamic inactivation toward various microbial species in planktonic and biofilm cultures. The review is mainly focused on biofilm-growing microrganisms because this form of growth poses a threat to chronically infected or immunocompromised patients and is difficult to eradicate from medical devices. We discuss the b...

OBJECTIVE To study the in vitro effects of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with the photosensitizer methylene blue (MB) and light against Enterococcus faecalis (ATCC 29212). MATERIALS AND METHODS The uptake and distribution of nanoparticles in E. faecalis in suspension was investigated by transmission electron microscopy (TEM) after incubation with PLGA complexed wit...

For several years, photodynamic therapy (PDT) has been a treatment option for skin conditions such as nonmelanoma skin cancer. Recently, this technique has been studied for skin infections, particularly those in which biofilms have formed. The antibacterial, immunoregulatory, and regenerative effect of PDT may enable healing of antibioticresistant infections and infections at sites with limited...