Polymorphonuclear leukocytes (PMNL) concentrate, transport, and release certain antimicrobial agents as they move in a chemotactic gradient. Antipyretic agents are frequently used in febrile patients receiving antimicrobial agents. Thus, the influence of ibuprofen, acetaminophen, and acetylsalicylic acid on uptake, transport, and release of azithromycin and moxifloxacin was studied. Uptake of t...

The antimicrobial efficacy of methanol and water extracts of seeds of the plant Swietenia macrophylla (Family: Meliaceae) was evaluated against selected pathogenic bacterial strains (Bacillus cereus MTCC 430, Klebsiella penumoniae MTCC 109, Pseudomonas aeruginosa MTCC 424, Escherichia  coli MTCC 443, Staphylococcus aureus MTCC 96, Salmonella typhimurium MTCC 98, Micrococcus luteus MTCC 106...

the purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the ctpa on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, q...

Photodynamic inactivation (PDI) combined with chitosan has been shown as a promising antimicrobial approach. The purpose of this study was to develop a chitosan hydrogel containing hydroxypropyl methylcellulose (HPMC), chitosan and toluidine blue O (TBO) to improve the bactericidal efficacy for topical application in clinics. The PDI efficacy of hydrogel was examined in vitro against the biofil...

Seven reported xanthate ligands and their new Fe(II) complexes of formulaNa[Fe(R-OCSS)3], where R is ethyl-, propyl-, butyl-, pentyl-, Hexyl-, heptyl- and octyl-xanthate have been synthesized. They have been characterized using elemental analysis, molar conductance, FT-IR, UV-Vis and 1H NMR spectroscopic techniques and melting-, decomposition-points for ligand...

Antimicrobial stewardship programs in hospitals seek to optimize antimicrobial prescribing in order to improve individual patient care as well as reduce hospital costs and slow the spread of antimicrobial resistance. With antimicrobial resistance on the rise worldwide and few new agents in development, antimicrobial stewardship programs are more important than ever in ensuring the continued eff...