has shadowed the success of infectious disease therapy. In his 1945 Nobel Prize acceptance speech, Alexander Fleming noted the danger of resistance: “It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body.... Moral: If you use penicillin, use enough” (...

A variety of compounds which are involved in the management of diseases of non-infectious aetiology have shown some antimicrobial activity in vitro, against bacteria and other microorganisms (13). Such compounds are called ìnon-antibioticsî. By the end of the nineteenth century the dyes were known to possess antimicrobial activity. Paul Ehrlich used methylene blue ñ one of phenothiazines compou...

Each year from 1981 through to 1988 the most common serotypes isolated from man in England and Wales and identified at the Division of Enteric Pathogens were S typhimurium, S enteritidis, and S virchow. In 1981 these three serotypes accounted for 45%, 12%, and 7% of isolations. The remaining 35% comprised strains belonging to a further 188 different serotypes, none of which accounted for more t...

One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs. Peptides of the defensin, cathelicidin, and histatin classes are found in humans. In the airways, alpha-defensins and the cathelicidin LL-37/hCAP-18 originate from neutrophils. beta-Defensins and LL-...

EDITORIAL article Front. Cell. Infect. Microbiol., 03 July 2023Sec. Antibiotic Resistance and New Antimicrobial drugs Volume 13 - 2023 | https://doi.org/10.3389/fcimb.2023.1219503

Antimicrobial drugs are used in many ways. They are used for man's health and as agents to help provide or preserve his food. Similarly they are used for animal diseases and as additives to animal feed in hopes of increasing average daily gain and feed efficiency. There are many variables which determine if the use is an efficacious one supported by scientific observation and documentation or i...

Rising rates of resistance to antimicrobial drugs among Enterobacteriaceae limit the choice of reliably active forms of these drugs. We evaluated the evidence on fosfomycin as a treatment option for infections caused by members of the family Enterobacteriaceae with advanced resistance to antimicrobial drugs, including producers of extended-spectrum beta-lactamase (ESBL). We systematically revie...

Health care-associated infections (HAIs) are a leading cause of in-hospital mortality and adverse events such as antimicrobial resistance. These infections place tremendous burdens on the health care system and create situations for misuse of antimicrobial drugs. Recognition of these factors has led professional societies, clinicians, and hospitals to develop programs to improve the management ...

resistant bacteria. We retrospectively identified 179 isolates in a clinical database. Clinical relevance, in vitro susceptibility, and length of parenteral antimicrobial drug use were obtained from patient records. For patients with hardwareor device-associated infections, those with C. striatum infections were matched with patients infected with coagulase-negative staphylococci for case–contr...

The currently available antimicrobial drugs suffer from toxicity, interactions with other drugs, insufficient pharmacokinetic properties, and the development of resistance. Thus, development of new antimicrobial agents with optimum pharmacokinetics and low toxicity is important. In this study, a series of flavanone, hydrazone derivatives have been prepared from flavanone under microwave irradia...