نتایج جستجو برای: antileukemic activity
تعداد نتایج: 1134946 فیلتر نتایج به سال:
Enchanced therapeutic effectiveness has been demonstrated by combining methotrexate and 5-fluorouracil in the treatment of murine leukemia L1210. Optimal combinations of the 2 drugs consistently showed greater antileukemic activity than optimal treatment with each drug by itself. The treatment schedules resulting in this enhanced activity were characterized by rela tively low and therapeuticall...
PURPOSE VNP40101M is a novel sulfonylhydrazine alkylating agent with broad antitumor activity in animal models. As alkylating agents are important antileukemia drugs, a Phase I and pharmacokinetic study of VNP40101M was conducted in patients with refractory or relapsed leukemias or poor-risk myelodysplastic syndromes (MDS). EXPERIMENTAL DESIGN VNP40101M was given as a single i.v. infusion ove...
Lintuzumab, a humanized anti-CD33 antibody, targets myeloid leukemia cells and has modest activity against acute myeloid leukemia (AML). To increase the antibody’s potency yet avoid nonspecific cytotoxicity seen with -emitting isotopes, lintuzumab was conjugated to the -emitters bismuth-213 (213Bi) and actinium-225 (225Ac). The 46-minute half-life of 213Bi limits its widespread use. Therefore...
Monoclonal antibodies have become an important modality for cancer therapy. Genetically engineered chimeric and humanized antibodies have demonstrated activity against both overt leukemia and minimal residual disease. High-dose radioimmunotherapy can potentially allow intensification of antileukemic therapy before bone marrow transplantation yet minimize radiation exposure to normal organs. Tar...
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