The Escherichia coli species is divided in phylogenetic groups that differ in their virulence and commensal distribution. Strains belonging to the B2 group are involved in extra-intestinal pathologies but also appear to be more prevalent as commensals among human occidental populations. To investigate the genetic specificities of B2 sub-group, we used 128 sequenced genomes and identified genes ...

In this module we present an overview of an electrical power system. The electrical power system is a network of interconnected components which generate electricity by converting different forms of energy, (thermal, hydro, and nuclear are the most common forms of energy converted) to electrical energy; and transmit the electrical energy to load centers to be used by the consumer. The system co...

When hybridization subtraction was used to enrich for sequences induced by heat shock in Chinese hamster cells, B2 sequences were found to be one of the major sequences enriched. With cloned B2 probes, we found that the level of the short, 0.1 to 0.6 kb, polyadenylated RNA polymerase III transcripts of this repetitive genetic element increased approximately 10 to 20 fold after heat shock. Trans...

We previously found that the SINE-encoded mouse B2 RNA binds RNA polymerase II and represses mRNA transcription during the cellular heat-shock response. In vitro B2 RNA assembles into preinitiation complexes on promoter DNA via its interaction with the polymerase, thus rendering the complexes inactive. With the goal of understanding which regions of B2 RNA are important for high-affinity bindin...

Type 2 bradykinin (B2)-receptor antagonists have been used to define the role of endogenous kinin peptides. However, interpretation of the effects of B2-receptor antagonists has been limited by lack of information concerning the effects of these antagonists on endogenous kinin and angiotensin peptide levels. If kinin levels were subject to short-loop-feedback regulation mediated through B2 rece...

We prove that the sumset {p2+b2+2n : p is prime and b, n ∈ N} has positive lower density. We also construct a residue class with an odd modulus that contains no integer of the form p2 + b2 + 2n. Similar results are established for the sumset {b1 + b2 + 2n 2 : b1, b2, n ∈ N}.

OBJECTIVE Ephrin-B2 plays a key role in vascular development. The purpose of this study was to elucidate the molecular mechanisms of ephrin-B2 signaling through the EphB receptor in endothelial cells and to determine whether ephrin-B2 contributes to in vivo angiogenesis in adult mice. METHODS AND RESULTS A chemotaxis assay on a polycarbonate membrane revealed that ephrin-B2/Fc chimeric protei...

Both bradykinin B2 and angiotensin II type 2 (AT2) receptors are known to stimulate renal production of nitric oxide (NO). To evaluate the individual contributions of AT2 and B2 receptors to renal NO production, we monitored renal interstitial, stable NO metabolites and cGMP by a microdialysis technique in conscious, bradykinin B2-null and wild-type mice (n=8 in each group) during low sodium in...

Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how b2-microglobulin (b2-M) supports lethal metastasis in vivo in human prostate, breast, lung, and renal cancer cells. b2-M mediates this process by activating epithelial to mesenchymal transition (EMT) to promote lethal bone and soft tissue metastases in host mice. b2-M interacts w...

The effect of dietary riboflavin (B2) supplementation and selenium (Se) source on the performance and Se metabolism of weanling pigs was studied. Pigs fed a B2-supplemented (10 mg/kg) casein-glucose diet for 18 d gained faster than pigs fed the B2-unsupplemented diet. Percentage active erythrocyte glutathione reductase (GR) declined rapidly when pigs were placed on the B2-unsupplemented diet an...