This study investigated the effects of Lime on Diarrhoea in Wistar rats. A total 60 rats were procured and randomly divided into 3 groups 20 animals each for three t-test models. The twenty healthy diarrhoea model fasted 6 hours prior to experiment but allowed free access water. 5 4 experiment. Established antidiarrhea models followed. test received various doses (97.65mg/kg, 195.3mg/kg, 390.6m...

BACKGROUND Rotavirus (RV) induces diarrhoea through a sequence of enterotoxic and cytotoxic effects. The former are NSP4-dependent, induce calcium-dependent chloride secretion and involve oxidative stress. Diosmectite (DS) is a natural clay that has been recommended as an active therapy for diarrhoea, but the mechanism of its effect is not clear. Electrical parameters may be used to measure the...

BACKGROUND The use of medicinal plants in the treatment of diseases has generated renewed interest in recent times, as herbal preparations are increasingly being used in both human and animal healthcare systems. Diarrhoea is one of the common clinical signs of gastrointestinal disorders caused by both infectious and non-infectious agents and an important livestock debilitating condition. Platea...

BACKGROUND Traditionally, Operculina turpethum has been used in a wide range of ailments such as, gastrointestinal disturbances and asthma. It is found in China, South Asia, Pacific Islands, and Australia. This study was aimed to provide a possible pharmacological basis for the medicinal use of O. turpethum in gut and airways disorders. METHODS Castor oil-induced diarrhoeal mice model and iso...

3 Wuster M, Herz A. Opiate agonist action of antidiarrhoeal agents in vitro and in vivo-findings in support for selective action. Naunyn Schmiedebergs Arch Pharmacol 1978;301:187-94. 4 Niemegeers CJE, McGuire JL, Heykants JJP, Janssen PAJ. Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. J Pharmacol Exp Ther 1979;210:327-33. 5 Van Nueten JM, Janssen PAJ, Fon...

Sir, Recommendations for the treatment of gastroenteritis in children have stressed the importance of oral rehydration solutions and withdrawal of milk feeds for 24 hours in bottle fed infants.' The use of antibiotics should be limited to specific indications such as giardiasis or shigellosis, and antidiarrhoeal agents should be avoided as they are ineffective and may be harmful.2 In view of th...

This study describes the spasmolytic, antidiarrhoeal, antisecretory, bronchodilatory and urinary bladder relaxant properties of Hyoscyamus niger to rationalize some of its medicinal uses. The crude extract of H. niger seeds (Hn.Cr) caused a complete concentration-dependent relaxation of spontaneous contractions of rabbit jejunum, similar to that caused by verapamil, whereas atropine produced pa...

OBJECTIVE To study the relationship between toxicity and the exposure to nelfinavir and saquinavir as part of a quadruple drug regimen. DESIGN The ADAM study is a randomized study to investigate the feasibility of induction-maintenance therapy in HIV-1 infection. METHODS HIV-1-infected patients with no prior use of antiretroviral treatment started induction therapy consisting of stavudine +...