OBJECTIVE We validated an algorithm designed to identify new or prevalent users of antidepressant medications via population-based drug prescription records. PATIENTS AND METHODS We obtained population-based drug prescription records for the entire Olmsted County, Minnesota, population from 2011 to 2012 (N=149,629) using the existing electronic medical records linkage infrastructure of the Ro...

Specific interventions included in the review Studies of RIMAs, i.e. MOC (18 to 600 mg) or BRO (93.1 to 150 mg/day) versus either placebo or another standard tricyclic antidepressant, selective serotonin re-uptake inhibitor (SSRI) or other class of antidepressant, were included. The active comparison groups included: diazepam, tranylcypromine, mianserin, isocarboxide, imipramine, amitriptyline,...

OBJECTIVE To compare the long-term clinical, quality-of-life, and economic outcomes after an initial prescription for fluoxetine, imipramine hydrochloride, or desipramine hydrochloride. DESIGN Randomized, controlled trial. SETTING Primary care clinics of a staff-model health maintenance organization in the Seattle, Wash, area. PATIENTS Four hundred seventy-one adults beginning antidepress...

Introduction: Bupropion is currently mainly used as an atypical antidepressant due to its psychotropic effects. In addition, it shows high potential in reducing withdrawal cravings addicts, which also the treatment of nicotinism. However, studies recent years have shown that may be useful other conditions.Aim study: Our aim was review known usage bupropion fields psychiatry, neurology and inter...

(1) OBJECTIVE: To examine the relationship between the choice of second-generation antidepressant drug treatment and long-term weight change; (2) METHODS: We conducted a retrospective cohort study to investigate the relationship between choice of antidepressant medication and weight change at two years among adult patients with a new antidepressant treatment episode between January, 2006 and Oc...

OBJECTIVE To carry out a metaanalysis of antidepressant studies to calculate the effect sizes for antidepressant effect in depressive disorder. METHOD A metaanalysis of all antidepressant studies that included an active comparison drug as well as placebo was used to calculate the effect size. Articles were selected from a MEDLINE search for the period January 1966 to June 1995. Forty-nine stu...

Depression in the elderly and very elderly, especially those in long-term care facilities, often is more difficult to treat than depression in young or middle-aged adults. Because this population may be more sensitive to the common adverse effects of many antidepressant drugs, particularly the anticholinergic side effects, administration of pharmacologic therapy for depression in the elderly re...

A new antidepressant, levomilnacipran, is the levorotatory enantiomer of milnacipran. The drug belongs to selective serotonin-norepinephrine reuptake inhibitors (SNRI) and has the highest noradrenergic selectivity of all members of this group of antidepressants. Clinical trials have confirmed the effectiveness of levomilnacipran in the treatment of depression. The drug was placed on the US mark...