Alzheimer hastalığı (AH) öncelikli olarak yaşlı popülasyonda görülen, klinik bellek ve bilişsel bozukluklar ile karakterize, ilerleyici nörodejeneratif bir hastalıktır. 
 Hastalığın etiyolojisinin henüz tam belirlenememiş olması, hasta popülasyonunun yıllar geçtikçe artması, radikal tedavinin olmayışı, tedavi bakım maliyetinin oldukça yüksek hastaların yaşam kalitesini düşürmesi gibi sebep...

  Alzheimer’s disease (AD) is a neurodegenerative disease that was characterized with deposit of beta amyloid (Aβ) aggregate in senile plaque. Oxidative damage to neurons and loss of cholinergic neurons in forebrain region are observed in this disease. Melissa officinalis is a medicinal plant from Lamiaceae family, used traditionally in the treatment of cognitive disorders. It has cholinomimeti...

The aim of this research was to investigate the antiproliferative and anticholinesterase activities of 11 extracts from 5 Annonaceae species in vitro. Antiproliferative activity was assessed using 10 human cancer cell lines. Thin-layer chromatography and a microplate assay were used to screen the extracts for acetylcholinesterase (AchE) inhibitors using Ellman's reagent. The chemical compositio...

The antimicrobial, antioxidant, and anticholinesterase activities of ethanolic seed extracts of twenty-one plant species from Brazilian semiarid region were investigated. The extracts were tested for antimicrobial activity against six bacteria strains and three yeasts. Six extracts presented activity against the Gram (-) organism Salmonella choleraesuis and the Gram (+) organisms Staphylococcus...

Acetylcholinesterase (AChE) inhibitor is a basic drug design recently used in treating Alzheimer’s disease (AD). However, butyrylcholinesterase (BuChE) also suggested to be responsible for the hydrolysis of acetylcholine (ACh) and its inhibition may benefit in the latter stage of AD. Nonetheless, the search for potent AChE and BuChE inhibitor is still in need, in curing this neurodegenerative d...