results: the mean age of participants in the experimental and control groups were 33.31 ± 7.47 and 34.38 ± 11.29 years, respectively. in the wright tube test for the hiv+ group, 71 individuals (79.8%) did not have an antibody against brucella spp., while 18 patients (20.2%) were positive for the antibody. according to the results of wright tube test for the control group, 63 (12.5%) participant...

BACKGROUND Primary antibody deficiency, the most common primary immunodeficiency disorder, represents a heterogeneous spectrum of conditions caused by a defect in any critical stage of B cell development and is characterized by impaired production of normal amounts of antigen-specific antibodies. OBJECTIVE This retrospective study aimed at description and analysis of demographic, clinical, im...

Among the primary antibody deficiency syndromes, severe selective IgM deficiency (also previously known as type V dysgammaglobulinaemia) is rare, and the majority of previous reports have indicated a fatal outcome. Three adult patients who were found to have a persistently low serum IgM are described. This deficiency was not obviously related to their presenting illness; in two of the patients,...

Protein and energy malnutrition and iron-deficiency anaemia are widespread among preschool children in India. Because of a poor antibody response in severely malnourished children admitted to hospital it has been suggested that mass vaccination programmes would not be effective in populations where malnutrition is widespread. Earlier studies by this institute, however, have shown that most chil...

CBA/N mice express an X-linked deficiency in their antibody response to many bacterial carbohydrates; we have shown recently that these antigens normally elicit antibody responses predominantly of the IgM and IgG3 isotypes. Here we demonstrate that mice, with the CBA/N phenotype have perferential deficiencies of IgM and IgG3 immunoglobulin expression, both when measured in serum and in cells se...

common variable immunodeficiency (cvid) and selective iga deficiency (sigad) are the most common primary antibody deficiencies. these two diseases may have coincidence in one family and sigad can progress to cvid which suggest common underlying genetic defects between sigad and cvid. this study was designed to find the prevalence of multiple cases in families of iranian patients with cvid or si...

Introduction: Common Variable Immune Deficiency (CVID) is the most prevalent form of severe antibody deficiency in children and adults. Most patients suffer recurrent, mainly sinopulmonary, infections. Despite adequate IVIG replacement therapy, chronic lung disease continues to be a main cause morbidity mortality. The term granulomatous-lymphocytic interstitial (GLILD) frequently used describe ...

RATIONALE Diverse B cell responses and functions may be involved in atherosclerosis. Protective antibody responses, such as those against oxidized lipid epitopes, are thought to mainly derive from T cell-independent innate B cell subsets. In contrast, both pathogenic and protective roles have been associated with T cell-dependent antibodies, and their importance in both humans and mouse models ...

recurrent ear, nose, and throat (ent) infections are common presenting symptoms in patients with primary antibody deficiencies , but sometimes they remain undiagnosed for many years and are subjected to different antibiotics because of a lack of experience in immunodeficiencies. in order to determin the frequency of ent symptoms among the patients with antibody deficiencies, 83 antibody deficie...