Some antibacterial agents have been shown to neutralize the biological properties of bacterial lipopolysaccharide (LPS). The aim of this study was to elucidate the role of gentamicin, tobramycin, imipenem, tigecycline, and isoniazid in affecting the production of nitric oxide (NO) induced by LPS in mice. Groups of mice were injected intraperitoneally with LPS alone, antibacterial agent alone, o...

BACKGROUND Antibacterial drug use is a major risk factor for bacterial resistance, but little is known about antibacterial use in US hospitals. The objectives of this study were to characterize trends in antibacterial use in a sample of US hospitals and to identify predictors of use. METHODS We measured systemic antibacterial use from validated claims data at 22 university teaching hospitals ...

conclusions as a result of the full range uv-vis scanning of the responsible band in the hptlc experiments (200-700 nm), the flavonoid was the most imaginable natural compound. results through the bioassay guided fractionation method, the greatest antibacterial activities were related to the n-hexane extract. it was also revealed that the effective anti-mrsa agent of the assessed plant was a re...

objective: this study aims to evaluate the antimicrobial activity, phytochemical studies and thin layer chromatography analysis of machine oil, hexane extract of seed oil and methanol extract of presscake& latex of jatropha curcas linn (family euphorbiaceae). materials and methods: j. curcas extracts were subjected to preliminary qualitative phytochemical screening to detect the major phytochem...

The prevention of microbial surface contamination has become most crucial in today’s health care system, and in food and pharmaceutical production. Human beings are often infected by microorganisms such as bacteria, viruses, and molds that often infect living environments. Silver nanoparticles or silver ions have been known to have strong inhibitory and bactericidal effects. Metallic nanopartic...

In the present research work three Pakistani medicinal plants were scrutinized for their antibacterial and phytotoxic potentials. The antibacterial and phytotoxic effects were determined for the crude methanolic extract and its subsequent solvent fractions. In case of antibacterial effect the chloroform and ethyl acetate fractions of all tested plants showed moderate antibacterial potential. Al...

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremi...

The increasing presence of drug-resistant bacterial infections among hospitalAbstract ised patients has resulted in greater numbers of patients receiving inappropriate antimicrobial treatment. This has led to the development of a novel paradigm guiding the administration of empirical antimicrobial therapy for patients with serious infections in the hospital setting. Antibacterial de-escalation ...