background and objectives : streptokinase is used clinically as an intravenous thrombolytic agent for the treatment of acute myocardial infarction and is commonly prepared from cultures of streptococcus equisimilis strain h46a. the objective of the present study was the production of streptokinase from strain h46a and purification by chemical reduction method. materials and methods: the rate of...

background: in spite of available, and sensitive screening assay for detection of hepatitis b virus surface antigen (hbsag), occasional cases of post-transfusion hepatitis b virus infection are still observed. the aim of the present study was to assess the prevalence of positive anti hepatitis b core (anti-hbc) and presence of hbv-dna in serum sample of healthy blood donors negative for both hb...

Background: In spite of available, and sensitive screening assay for detection of hepatitis B virus surface antigen (HBsAg), occasional cases of post-transfusion hepatitis B virus infection are still observed. The aim of the present study was to assess the prevalence of positive anti hepatitis B core (anti-HBc) and presence of HBV-DNA in serum sample of healthy blood donors negative for both HB...

determination of streptokinase activity is usually accomplished through two assay methods: a) clot lysis, b) chromogenic substrate assay. in this study the biological activity of two streptokinase products, namely streptase®, which is a native product and heberkinasa®, which is a recombinant product, was determined against the third international reference standard using the two forementioned a...

background: invariant natural killer cells (inkt) are an important immunoregulatory t cell subset. currently several flow cytometry-based approaches exist for the identifi-cation of inkt cells, which rely on using the 6b11 monoclonal antibody or a combina-tion of anti-vα24 and anti-vβ11 antibodies. objective: the aim of this study was to compare the ability of two flow cytometry-based methods f...

background: systemic lupus erythematosus (sle) is a chronic autoimmune disease which is characterized by b-cell abnormality and auto-antibody generation. since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with sle. objective: to investigate humoral immunity and specific-antibody formation in response to a...

neonatal tetanus (nt) is a leading cause of neonatal mortality in many parts of the world. tetanus is a vaccine-preventable disease and is second only to measles worldwide as a cause of childhood mortality. in this study the various irnrnunoglobulin classes of anti-tetanus antibody in the sera of 105 iranian women of childbearing age (13-45 years) were titrated by enzyme linked immunosorbent as...