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Intracranial aneurysms have rarely been reported in association with complex partial seizures. We report five cases of complex partial seizures where aneurysms were found either accidentally or through investigations in these patients. MRI scans and angiograms revealed these aneurysms and in one patient several aneurysms were found. Four patients were treated with GDC coil embolisation with fol...

Effects of neuropeptide y on single neuronal firing patterns in a genetic rat model of absence epilepsy Date: Effects of neuropeptide y on single neuronal firing patterns in a genetic rat model of absence epilepsy 1 ABSTRACT Absence seizures are most common type of generalized seizures where brain goes into abnormal pathological rhythm characterized by bilateral and synchronous 3Hz spike and wa...

The immature brain is exceptionally susceptible to seizures. However, it remains unclear whether seizures occurring during development affect critical processes underlying neural circuit formation, leading to long-term functional consequences. Here we characterize a novel in vivo model system of developmental seizures based on the transparent albino Xenopus laevis tadpole, which allows direct e...

Levetiracetam is a commonly used drug in today’s world for long term management of partial as well generalized seizures mainly due its major advantage that has so few and non-threatening side effects[1].In the following case scenario, we show how 70 years old male presented with severe hyperkalemia after no other common culprits were seen, it was thought to be effect therapy levetiracetam disco...

Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subse...

Epilepsy, the commonest serious neurological condition, is associated with an increased risk in premature deaths, including an estimated 500 sudden unexpected deaths (SUDEP) per year in the UK. In some patients seizures are associated with cardiac arrhythmias, which are thought to be a major factor in SUDEP. Omega-3 fatty acids have been shown to reduce cardiac arrhythmias in animal studies and...

OBJECTIVE The prevalence of active epilepsy is about 0.5-1%, and approximately 70% of patients are cured with first anti-epileptic drugs and the remaining patients need multiple drugs. Pregabalin as an add-on therapy has a postive effect on refractory seizures in adults. To the best of our knowledge, there is no research with this drug in childhood epilepsy. We use pregabalin in children with r...

Intractable epilepsy is a common clinical problem in pediatrics and approximately 13% of children with epilepsy experience intractable seizures. To determine the efficacy of pyridoxine in treating seizures, 30 infants and children with recurrent seizures were enrolled in the present study. All of them were treated with high-dose oral pyridoxine (40 mg/kg/day), as an adjunct to antiepileptic...

Carbamazepine is an anticonvulsant that commonly used in neurological and psychiatric patients to treat epileptic seizures, neuropathic pain, or bipolar disorder. side effects, as well effects of many antiepileptic drugs, include cardiotoxic such atrioventricular block, bradycardia, cardiac rhythm disorders. However, carbamazepine has also been reported have antiarrhythmic, normotimic, membrane...