نتایج جستجو برای: anti ischemic activity
تعداد نتایج: 1497295 فیلتر نتایج به سال:
The cell surface receptor alpha4 integrin plays a critical role in the homing, engraftment, and maintenance of hematopoietic progenitor cells (HPCs) in the bone marrow (BM). Down-regulation or functional blockade of alpha4 integrin or its ligand vascular cell adhesion molecule-1 mobilizes long-term HPCs. We investigated the role of alpha4 integrin in the mobilization and homing of BM endothelia...
Cannabis contains the psychoactive component delta⁸-tetrahydrocannabinol (delta⁸-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol. It is well-known that delta⁸-THC and other cannabinoid CB₁ receptor agonists are neuroprotective during global and focal ischemic injury. Additionally, delta⁸-THC also mediates psychological effects through the activation of ...
Inflammation after stroke consists of activation of microglia/astrocytes in situ and infiltration of blood-borne leukocytes, resulting in brain damage and neurological deficits. Mounting data demonstrated that most natural components from medicinal plants had anti-inflammatory effects after ischemic stroke through inhibiting activation of resident microglia/astrocytes within ischemic area. Howe...
Abstract Nature has been a wellspring of therapeutic operators for a huge number of years and an exceptional number of present day drugs have been secluded from common sources. Higher plants, as wellsprings of restorative mixes, have kept on assuming a prevailing part in the support of human wellbeing since old circumstances. More than half of all cutting edge clinical medications are of...
background: immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease (ihd). objective: the aim of this study was to evaluate the serum levels of several autoantibodies including rheumatoid factor (rf), anti-nuclear antibodies (ana), anti-small nuclear ribonucleoprotein (anti-sm), anti-phosphatidylserine (anti-ps) and anti-car...
Tissue-type plasminogen activator (tPA) is the only treatment for ischemic stroke. However, tPA could induce the intracranial hemorrhage (ICH), which is the main cause of death in ischemic stroke patient after tPA treatment. At present, there is no treatment strategy to ameliorate tPA-induced brain injury after ischemia. Therefore, we investigated the effect of pre-treated isoflurane, which is ...
The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the extracellular space. Here we show that treatment with neutralizing anti-HMGB1 monoclonal antibody (mAb; 200 microg, twice) remarkably ameliorated brain infarction induced by 2-h occlusion of the middle cerebral artery in rats, even when the mAb...
BACKGROUND Experimental studies suggest that activation of the bradykinin B2 receptor is an important trigger of ischemic PC. However, it is unknown whether bradykinin can precondition human myocardium against ischemia in vivo. Multicenter clinical trials have demonstrated an anti-ischemic effect of angiotensin-converting enzyme inhibitors, which has been postulated to result from potentiation ...
Introduction: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (Nox2) is one of the predominant sources of ROS production during myocardial ischemia-reperfusion and can be induced by angiotensin II. The evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. The mechanism...
abstract background and objective: glycyrrhizaglabra l. is one of the most widely used medicinal herbs in golestan province that is known for its anti-inflammatory, carminative, antiviral, anti-infection and anti-ulcer properties in iranian traditional medicine. this study aimed to assess the anti-bacterial and anti-oxidative activity of g. glabrafrom the golestan province. method...
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