Background Colon cancer continues to be the third most commonly occurring around globe with both lifestyle-related risk factors and genetic dispositions. Owing increased incidence of disease, there is a need find new treatment options which are easily accessible less toxic cells. Cynaropicrin, sesquiterpene extract from artichoke plant exhibits varied properties such as anti-inflammatory, anti-...

Currently, herbs have been investigated for novel bioactivities and improvement of traditional therapeutic effectiveness. Among them, Andrographis paniculata, with the active component Andrographolide, is well recognized as an anti-inflammatory, anti-bacterial, anti-cancer, anti-hypertensive, anti-hyperglycaemic, hepatoprotective, anti-hyperlipidaemic compound. However, Andrographolide has poor...

actinomycetes were isolated from marine sediment samples collected from the east coast of chennai, tamil nadu, india. well diffusion and agar plug methods were used for the evaluation of antibiotic production by these isolates against drug resistant methicillin- resistant staphylococcus aureus (mrsa) and vancomycin resistant enterococci (vre). the potential isolate vitbrk2 was mass cultured for...

Antibody drug conjugates (ADCs) are a new class of drugs that combine chemosynthetic with antibody through linker. the targeting characteristics traditional cytotoxic small molecule drugs, while reducing side effects both making them kind “biological missile” and representing relatively evolving anti-cancer drugs. Antibody-coupled currently used in many solid tumors, this article reviews clinic...

Pistacia atlantica is one of the species of Anacardiaceae that grows in the wild in different regions of Iran. Traditionally, anacardiaceae family has antibacterial, fungicidal and cytotoxic properties. Therefore, the present study was designed to investigate the possible cytotoxic and anti-proliferative properties of Baneh gum. Cytotoxicity of the plant gum was determined using MTT assay on MC...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

Objective: Zerumbone (ZER) is a well-known natural compound that has been reported to have anti-cancer effect. Thus, this study investigated the ZER potential inhibit Thymidine Phosphorylase (TP) and ability trigger Reactive oxygen species (ROS)-mediated cytotoxicity in non-small cell lung cancer, NCI-H460, line. Material Method: The antiangiogenic activity for was evaluated by using thymidine ...

Cancer is one of the main cause of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties...